PMID: 11926749Apr 3, 2002Paper

Hypogammaglobulinemia after heart transplantation: impact of pre-emptive use of immunoglobulin replacement (CytoGam) on infection and rejection outcomes

Transplant Infectious Disease : an Official Journal of the Transplantation Society
Mohamad H YamaniR Starling

Abstract

Hypogammaglobulinemia (HGG) in solid organ transplant (SOT) patients confers an increased risk of opportunistic infections and poorer outcomes. Severe HGG (IgG < 350 mg/dL) after heart transplantation may follow intensification of immunosuppressive therapy and the resultant increased risk of opportunistic infections, particularly cytomegalovirus (CMV) disease. Evaluation of the effects of replacement therapy using intravenous immunoglobulin (CMV-IGIV, CytoGam) was conducted in cardiac transplant recipients and the data matched with a historical control group. Patients with severe HGG who received pre-emptive replacement therapy had significantly fewer opportunistic infections (P < 0.001) and episodes of rejection (grade > or = 3; P = 0.03 and grade > or = 2; P = 0.04) compared with the control group.

References

Feb 24, 2001·Transplantation·N S GoldfarbJ R Maurer
Apr 11, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·M H YamaniR C Starling
Jun 29, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·R CoralesR K Avery

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Citations

Oct 8, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·James A NathanJohn Wallwork
Nov 22, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Mohamad H YamaniRandall C Starling
Sep 5, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael HaleyNaomi P O'Grady
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Jun 24, 2005·Transplantation·Steven M KawutSelim M Arcasoy
Nov 30, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Peter BorosJonathan S Bromberg
Apr 21, 2011·Expert Review of Anti-infective Therapy·Javier CarboneElizabeth Sarmiento
Jun 30, 2019·Clinical Transplantation·Karthik SanthanakrishnanRajamiyer Venkateswaran
Aug 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D F FlorescuU Sandkovsky
Oct 26, 2016·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Elizabeth SarmientoJavier Carbone
Mar 29, 2013·Cardiology in Review·Diana F FlorescuIoana Dumitru
Dec 30, 2014·Clinical and Experimental Immunology·S JollesI N van Schaik
Sep 27, 2018·Transplantation Direct·Andrej A PetrovJoseph M Pilewski
Feb 26, 2019·Frontiers in Immunology·Smita Y PatelStephen Jolles
Oct 7, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Margaret NewmanDavid Pitrak
Jan 10, 2014·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Akihiro OhsumiHiroshi Date
Dec 13, 2018·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Alicia B LichvarAndrej A Petrov
Jan 1, 2014·Current Treatment Options in Infectious Diseases·Ban Hock Tan
Aug 30, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Karam M ObeidCelalettin Ustun

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