Hypogammaglobulinemia and Nocardia brain abscesses

Neurosurgery
K J MurrayS D Douglas

Abstract

The host defense responses to Nocardia asteroides are not known. We have investigated a patient with common variable adult onset hypogammaglobulinemia who developed fatal disseminated nocardiosis. The patient had low levels of serum immunoglobulins; the total lymphocyte count was normal as were the percentages of circulating T and B cells. Transmission electron microscopic studies demonstrated typical N. asteroides within the brain parenchyma and nonspecific inflammatory changes in the central nervous system. The findings suggest that humoral immunity may play a major role in the host defense of patients with this disease.

Citations

Jun 29, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·R CoralesR K Avery
Oct 1, 1989·Australian and New Zealand Journal of Medicine·G K HerkesR Joffe
Nov 17, 2020·Frontiers in Immunology·Rubén Martínez-Barricarte
Apr 1, 1994·Clinical Microbiology Reviews·B L Beaman, L Beaman

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