PMID: 6405099May 1, 1983Paper

Hypogastrinemia in streptozotocin diabetes with islet transplantation--reconstitution

The Journal of Surgical Research
P J FabriK Reemtsma

Abstract

Gastrin is present in normal mammalian pancreatic islets, as well as in the antrum and duodenum. Serum gastrin levels are responsive to many physiologic and pharmacologic factors including hyperglycemia, somatostatin, and glucagon. To evaluate the effects of streptozotocin diabetes and islet transplantation on gastrin homeostasis, young, adult, male Lewis rats underwent streptozotocin diabetes alone (N = 14), diabetes plus intraperitoneal islet isografts (N = 22), or sham operation alone (N = 18). Streptozotocin reduced fasting gastrin immunoreactivity (107 pg/ml +/- 26 mean +/- SEM) compared to controls (256 pg/ml +/- 31) (P less than 0.001). Islet isotransplantation resulted in restoration of fasting gastrin immunoreactivity (230 pg/ml +/- 19) to levels significantly greater than diabetics (P less than 0.001) and comparable to control animals (P = NS). Normalization of serum gastrin levels occurred within one month of transplantation and persisted for up to 14 months. In addition, media from cultures of 4/7 dispersed neonatal rat pancreas cultures contained gastrin immunoreactivity. Streptozotocin diabetes produces hypogastrinemia; intraperitoneal islet isotransplantation normalizes fasting gastrin immunoreactivity. Rat islet...Continue Reading

References

May 1, 1975·Transplantation·C WeberK Reemtsma
Jul 1, 1978·Diabetes·J C Brown, S C Otte
Jun 1, 1971·Diabetes·M H Greider, J E McGuigan
Aug 1, 1974·Diabetologia·F LotstraW Gepts
Jun 1, 1973·The Journal of Clinical Investigation·J F Rehfeld, F Stadil

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Citations

Jul 29, 1998·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·G WieczorekE Perentes

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