PMID: 8971988Nov 1, 1996Paper

Hypoglossal and phrenic motoneuron responses to serotonergic active agents in rats

Respiration Physiology
C R Richmonds, D W Hudgel

Abstract

5-Hydroxytryptamine (serotonin, 5-HT) affects upper airway and chest wall inspiratory muscle control. The purpose of this study was to investigate the relative interaction of serotonergic agents on these two muscle groups. We measured the responses of the hypoglossal and phrenic nerves to the systemic administration of serotonergic-active agents and determined the receptor types through which these agents act in anesthetized, vagotomized, paralyzed and artificially ventilated rats. The serotonin precursor, L-5-hydroxytryptophan (L-5-HTP) produced equivalent stimulation of phasic inspiratory activity of the hypoglossal and phrenic nerves. General serotonin antagonists produced significant and equivalent diminution of both motoneuron pools. Specific 5-HT1A stimulation and 5-HT1C/2 antagonism enhanced ventilatory activity. We conclude: (1) a baseline level of serotonergic input to hypoglossal and phrenic motoneuron pools was present, (2) different 5-HT receptors had different effects on ventilatory neural activity, and (3) hypoglossal and phrenic motoneuron pools responded similarly to the serotonergic agents given.

References

Aug 1, 1987·Respiration Physiology·E B Olson
Dec 1, 1980·Respiration Physiology·D E MillhornT G Waldrop
Jul 1, 1993·Respiration Physiology·Y OkuD W Hudgel
Feb 1, 1996·American Journal of Respiratory and Critical Care Medicine·S C VeaseyJ C Hendricks

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Citations

Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Sigrid C Veasey
Nov 12, 2003·Respiratory Physiology & Neurobiology·K D O'HalloranA Bradford
Apr 2, 2003·Pharmacology, Biochemistry, and Behavior·Richard B Berry, Linda F Hayward
Feb 18, 1998·Current Opinion in Neurobiology·B L Jacobs, C A Fornal
Apr 24, 2001·American Journal of Respiratory and Critical Care Medicine·S C Veasey
Oct 31, 2002·American Journal of Respiratory and Critical Care Medicine·Polina Fenik, Sigrid C Veasey
Jul 16, 2005·American Journal of Respiratory and Critical Care Medicine·Sandeep SoodRichard L Horner
Nov 3, 2010·Respiratory Physiology & Neurobiology·Ivana PavlinacMaja Valic
Jul 25, 2006·The International Journal of Neuroscience·Reuven Sandyk
Apr 27, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andrew D RayGaspar A Farkas
Nov 14, 2001·Current Opinion in Pulmonary Medicine·S C Veasey
Sep 14, 1999·The American Journal of Physiology·R Kinkead, G S Mitchell
Dec 22, 2010·European Journal of Medical Research·M PozdzikM Pokorski
Dec 22, 1999·Journal of Neurophysiology·M B Lips, B U Keller
Sep 28, 2000·Journal of Applied Physiology·S Y Zhou, H G Goshgarian

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