PMID: 9006228Oct 1, 1996Paper

Hypoglycaemia induces emotional disruption

Patient Education and Counseling
M A MerbisR J Heine

Abstract

This study investigated how hypoglycaemia affects mood, whether psychological characteristics mediate an emotional disturbance during hypoglycaemia. Ten IDDM patients (1 female) were studied, aged [mean (range)] 28 (20-37) years, body mass index (BMI) 23.4 (19.6-25.7) kg/m2, diabetes duration 11 (7-15) years, HbA1c 7.5 (6.0-8.7)%. Patients underwent a standardized stepwise, hypoglycaemic, hyperinsulinaemic clamp, performed in steps of 0.5 mmol/l from 4.0 mmol/l to a glucose nadir of 2.0 mmol/l. At euglycaemia, the Symptom Checklist-90 (SCL-90) was administered. The Profile of Mood States (POMS) was completed at 4.0 and 2.5 mmol/l, while the feelings chart of the COOP/WONCA was filled out at euglycaemia and all hypoglycaemic steps. The t-test for the POMS demonstrated a significant increase for anger (P < 0.05). COOP/WONCA scores displayed a progressive negative change in mood for each hypoglycaemic step, albeit with a large interindividual variability. Hostility (SCL-90) significantly interacted with anger (POMS) at 2.5 mmol/l (P < 0.05). Progression of hypoglycaemia negatively alters the overall mood state. IDDM patients characterised by high scores on hostility (SCL-90) apparently are more prone to experience an increase in a...Continue Reading

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Citations

Aug 27, 1999·Physiology & Behavior·R J McCrimmonI J Deary
Apr 23, 2003·Biological Psychology·Norbert HermannsT Haak
Aug 13, 2008·International Journal of Behavioral Medicine·Joyce P YiKatie Weinger
Mar 30, 2007·Diabetes, Obesity & Metabolism·J B McGillD S H Bell
Jul 3, 2003·Social Work in Health Care·Vaughn A DeCoster
Feb 9, 2010·International Journal of Analytical Chemistry·Mahmoud A OmarTamer Z Attia
Feb 4, 2021·Endocrinology, Diabetes & Metabolism·Linda T MuijsFrank J Snoek

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