Hypoglycaemic and antihyperglycaemic effects of Trigonella foenum-graecum leaf in normal and alloxan induced diabetic rats

Journal of Ethnopharmacology
J A Abdel-BarryM H Al-Hakiem

Abstract

The aqueous and alcoholic extracts of Trigonella foenum-graecum leaf were tested for hypoglycaemic activity in normal and alloxan-diabetic rats. Graded amounts (0.06, 0.2, 0.5, 1 g/kg, i.p. and 1, 2, 8 g/kg, p.o.) of the aqueous extract of Trigonella foenum-graecum leaf when given to both normal and alloxan-diabetic rats, a significant reduction of blood glucose concentration was noticed. On the other hand ethanolic extract of Trigonella foenum-graecum leaf produced no reduction in blood glucose concentration in normal rats but intra-peritoneal administration of 0.8 g/kg of the ethanolic leaf extract to diabetic rats produced a significant reduction of blood glucose concentration (p < 0.02) at 2 and 24 h only. Intraperitoneal and oral acute toxicity (LD50) and target organ effects were studied for the aqueous extract of Trigonella leaf in mice. LD50 of i.p. and oral administration were 1.9 and 10 g/kg respectively. The main organ affected after i.p. administration of the aqueous extract was the liver while oral administration of the aqueous extract of Trigonella did not produce any sign of organ damage. These results suggest that the aqueous extract of Trigonella foenum-graecum leaves given both orally and intraperitoneally pos...Continue Reading

References

Sep 1, 1989·Diabetes Care·C J Bailey, C Day
Jan 1, 1988·Journal of Ethnopharmacology·M A Ajabnoor, A K Tilmisany
Jan 1, 1954·Journal of the History of Medicine and Allied Sciences·V PESET

❮ Previous
Next ❯

Citations

Jan 13, 2012·Journal of Physiology and Biochemistry·Ahmed Amir Radwan SayedFathy Fahim Abd el-Latif
May 22, 2002·Journal of Ethnopharmacology·J K GroverV Vats
Nov 5, 2002·Journal of Ethnopharmacology·Fátima Regina Mena Barreto SilvaEliandra de Sousa
Mar 18, 2000·Journal of Ethnopharmacology·J A Abdel-Barry, M H Al-Hakiem
Sep 24, 2005·Journal of Medicinal Food·B Annida, P Stanely Mainzen Prince
May 1, 2008·AAPS PharmSciTech·Mukesh S SikarwarS D Parial
Mar 1, 2008·Indian Journal of Pharmacology·Mohammad Reza Vaez MahdaviTourandokht Baluchnejadmojarad
Nov 1, 2008·Indian Journal of Pharmacology·E Edwin JaraldD C Jain
Dec 8, 2006·Annals of the New York Academy of Sciences·Amr AminErnest Adeghate
Apr 17, 2015·In Silico Pharmacology·Chelsea N Powers, William N Setzer
Oct 12, 2007·Journal of Biochemistry and Molecular Biology·Yaping ZhaoJeong-Chae Lee
Oct 10, 2013·Pharmaceutical Biology·Umesh C S Yadav, Najma Z Baquer
Mar 8, 2017·Molecular Nutrition & Food Research·Kalyan C Nagulapalli VenkataAnupam Bishayee
Feb 15, 2017·Journal of Complementary & Integrative Medicine·Siddhi Manohar BagweKedar S Prabhavalkar
May 9, 2006·Journal of Ethnopharmacology·Pulok K MukherjeePeter J Houghton
Mar 30, 2017·Journal of Basic and Clinical Physiology and Pharmacology·Anthoneth Ndidi EzejioforOrish Ebere Orisakwe
Sep 17, 2009·Human & Experimental Toxicology·A Ismail KhanK Balasubramanian
Nov 5, 2003·Phytotherapy Research : PTR·T Devasena, Venugopal P Menon
Jul 13, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Amol V PansareVishwanath R Patil
Jun 28, 2005·British Journal of Pharmacology·Maleppillil Vavachan VijayakumarManoj Kumar Bhat
Dec 20, 2005·International Journal of Food Sciences and Nutrition·K Srinivasan
Oct 29, 2010·Pharmaceutical Biology·Amal Al-Aboudi, Fatma U Afifi
Mar 21, 2019·Animal Models and Experimental Medicine·Xiao-Yan LiXuan-Cheng Lu
Jul 12, 2017·Frontiers in Pharmacology·Jorge M Alves-SilvaLígia Salgueiro
May 24, 2006·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·S P LiK W K Tsim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.