Hypoglycaemic effects of myrtle oil in normal and alloxan-diabetic rabbits

Journal of Ethnopharmacology
Aylin SepiciErdem Yesilada

Abstract

Myrtus communis L. (Myrtaceae) leaves as well as the volatile oil (Myrtii Oleum; MO) obtained from the leaves are used to lower the blood glucose level in type-2 diabetic patients in Turkish folk medicine. However, little attention has been paid to the therapeutic use of this plant. The present study was designed to investigate the oral hypoglycaemic activity of single and multiple doses of MO in normal and alloxan-diabetic rabbits. MO did not show any effect in normoglycaemic rabbits either in single or multiple dose administrations, but a good hypoglycaemic activity was observed 4 h after the administration to diabetic animals at 50 mg/kg. To investigate the effect of MO on repeated administration in both normal and diabetic rabbits, it was administered in 50 and 100 mg/kg doses once a day for one week. MO significantly lowered blood glucose by 51% in alloxan-diabetic rabbits on the fourth hour and the following days at a dose of 50 mg/kg (P < 0.001). The hypoglycaemic dose (50 mg/kg) was also determined by performing the oral glucose tolerance test (OGTT) in normal rabbits. The hypoglycaemic effect of the MO was 21% higher in rabbits, which received the glucose load orally, when compared with control group. However, MO did n...Continue Reading

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Citations

Mar 3, 2012·Applied Microbiology and Biotechnology·Yeu-Ching Shi, Tzu-Ming Pan
Jan 1, 2012·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Adewale Adeneye AdejuwonEsther Oluwatoyin Agbaje
Mar 6, 2012·International Journal of Food Sciences and Nutrition·P C LekshmiA Nirmala Menon
Nov 15, 2006·Journal of Ethnopharmacology·Aylin Sepici-DincelErdem Yeşilada
Aug 26, 2010·Journal of the Science of Food and Agriculture·Yeu-Ching Shi, Tzu-Ming Pan
Feb 6, 2014·Phytotherapy Research : PTR·Ghazal AlipourHossein Hosseinzadeh
Jun 3, 2015·Journal of Biochemical and Molecular Toxicology·Kenan IzgiCagri Sakalar
Sep 9, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Idris Ahmed Issa, Mohammed Hussen Bule
Mar 29, 2011·Journal of Ethnopharmacology·Prakash R ItankarArun T Patil
Dec 25, 2012·Journal of Ethnopharmacology·Bahar Gürdal, Sükran Kültür
Dec 3, 2013·Microbiological Research·Verica Aleksic, Petar Knezevic
Mar 2, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·M Mahboubi, F Ghazian Bidgoli
Oct 4, 2016·Journal of Ethnopharmacology·Mohaddese Mahboubi
Jul 23, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Philip F BuildersMichael U Adikwu
Jun 25, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hakam Alkhateeb, Arend Bonen
Jul 19, 2020·International Journal of Molecular Sciences·Axelle Septembre-MalaterrePhilippe Gasque
Dec 1, 2021·Applied Biochemistry and Biotechnology·Ahmet Gokhan AggulMine Gulaboglu

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