Abstract
Hypoglycemia is one of the major barriers in optimizing glycemic control. In type 2 diabetes, hypoglycemia is associated with multiple morbidities (eg, myocardial ischemia, cardiac arrhythmia, stroke, dementia, psychosocial dysfunction, obesity, microvascular complications, cancer, and diseases of respiratory, digestive, and dermatological systems). Risk factors associated with hypoglycemia in patients with type 2 diabetes include old age, long disease duration, low body mass index, high baseline glycated hemoglobin (HbA1c), treatment with insulin and sulphonylurea, renal dysfunction, albuminuria, reduced level of low density lipoprotein cholesterol, low triglyceride and depression. There are considerable overlaps between phenotypes associated with severe hypoglycemia and all-site cancer suggesting that hypoglycemia may be a marker of vulnerability. In patients with severe hypoglycemia, comprehensive assessment is recommended to detect silent conditions, such as renal dysfunction, cancer, depression as well as review of treatment strategies including drug use to prevent morbidities and mortality.
References
May 1, 1995·Diabetes Research and Clinical Practice·Y OhkuboM Shichiri
Nov 8, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·W Y SoC S Cockram
Feb 25, 2003·Critical Care Nursing Clinics of North America·Daleen AragonMaureen Covelli
Apr 30, 2003·Diabetes Care·Cyrus DesouzaVivian Fonseca
Dec 8, 2004·Endocrine Reviews·Bieke F SchrijversAllan Flyvbjerg
Jul 30, 2005·Diabetes, Obesity & Metabolism·Roderick E Warren, Brian M Frier
Mar 9, 2007·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Ronald C W MaJuliana C N Chan
Sep 4, 2007·Lancet·Anushka PatelB Williams
Jan 29, 2008·Current Diabetes Reviews·Robert P Hoffman
May 8, 2008·Diabetes/metabolism Research and Reviews·Rohana J Wright, Brian M Frier
Jun 10, 2008·The New England Journal of Medicine·Anushka PatelFlorence Travert
Jun 10, 2008·The New England Journal of Medicine·UNKNOWN Action to Control Cardiovascular Risk in Diabetes Study GroupWilliam T Friedewald
Aug 30, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Xilin YangJuliana C N Chan
Sep 12, 2008·The New England Journal of Medicine·Rury R HolmanH Andrew W Neil
Dec 19, 2008·The New England Journal of Medicine·William DuckworthUNKNOWN VADT Investigators
Dec 20, 2008·Circulation·Jay S SkylerUNKNOWN American Heart Association
Apr 16, 2009·JAMA : the Journal of the American Medical Association·Rachel A WhitmerJoseph V Selby
May 9, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Maureen F MoenJeffrey C Fink
Jul 14, 2009·Diabetes Care·Xilin YangJuliana C N Chan
Jan 12, 2010·BMJ : British Medical Journal·Denise E BondsMary Ellen Sweeney
May 12, 2010·International Journal of Clinical Practice·S Del PratoUNKNOWN Global Partnership for Effective Diabetes Management
May 27, 2010·Diabetes/metabolism Research and Reviews·Paolo PozzilliStefano Del Prato
May 29, 2010·Diabetes Care·Cyrus V DesouzaVivian Fonseca
Sep 16, 2010·Free Radical Biology & Medicine·Simone ReuterBharat B Aggarwal
Oct 12, 2010·The New England Journal of Medicine·Sophia ZoungasUNKNOWN ADVANCE Collaborative Group
Mar 4, 2011·The New England Journal of Medicine·Sreenivasa Rao Kondapally SeshasaiUNKNOWN Emerging Risk Factors Collaboration
Sep 6, 2011·Maturitas·Kyaw SoeGül Bahtiyar
Dec 17, 2011·Diabetes, Obesity & Metabolism·X L YangJ C N Chan
May 9, 2012·Current Diabetes Reports·Alice P S Kong, Juliana C N Chan
Jun 14, 2012·Expert Opinion on Drug Safety·Berit InksterBrian M Frier
Dec 12, 2012·Diabetes Care·Pai-Feng HsuShao-Yuan Chuang
Dec 20, 2012·Endocrine-related Cancer·Xilin YangJuliana C N Chan
Jun 12, 2013·JAMA Internal Medicine·Kristine YaffeUNKNOWN Health ABC Study
Jul 20, 2013·Current Medical Research and Opinion·Carl V AscheMark Aagren
Aug 31, 2013·Diabetes Care·Julia LawtonUNKNOWN U.K. NIHR DAFNE Study Group
Nov 12, 2013·Acta Diabetologica·Charles Nordin
Apr 17, 2014·Diabetes Technology & Therapeutics·Lin XieOnur Baser
Apr 24, 2014·Diabetes·Elaine ChowSimon R Heller
Jun 15, 2014·BMC Endocrine Disorders·Alice P S KongJuliana C N Chan
Oct 8, 2014·Nature Reviews. Endocrinology·Brian M Frier
Oct 29, 2014·Journal of Diabetes·Yuying ZhangUNKNOWN China Depression in Chinese Patients with Type 2 Diabetes (DD2) Study Group
Dec 10, 2014·Diabetes Care·Jessica L HardingDianna J Magliano
Dec 30, 2014·Diabetes Care·Silvio E InzucchiDavid R Matthews
Mar 25, 2015·Nature Reviews. Endocrinology·Xilin YangJuliana C N Chan
Apr 24, 2015·Medicine·Chia-Jen ShihYung-Tai Chen