Hypoglycemia and Islet Dysfunction Following Oral Glucose Tolerance Testing in Pancreatic-Insufficient Cystic Fibrosis.

The Journal of Clinical Endocrinology and Metabolism
Marissa J KilbergAndrea Kelly

Abstract

Oral glucose tolerance test (OGTT)-related hypoglycemia is common in pancreatic-insufficient cystic fibrosis (PI-CF), but its mechanistic underpinnings are yet to be established. To delineate the mechanism(s) underlying OGTT-related hypoglycemia. We performed 180-minute OGTTs with frequent blood sampling in adolescents and young adults with PI-CF and compared results with those from a historical healthy control group. Hypoglycemia (Hypo[+]) was defined as plasma glucose <65 mg/dL. We hypothesized that CF-Hypo[+] would demonstrate impaired early phase insulin secretion and persistent late insulin effect compared with control-Hypo[+], and explored the contextual counterregulatory response. OGTT 1-hour and nadir glucose, insulin, C-peptide, and insulin secretory rate (ISR) incremental areas under the curve (AUC) between 0 and 30 minutes (early) and between 120 and 180 minutes (late), and Δglucagon120-180min and Δfree fatty acids (FFAs)120-180min were compared between individuals with CF and control participants with Hypo[+]. Hypoglycemia occurred in 15/23 (65%) patients with CF (43% female, aged 24.8 [14.6-30.6] years) and 8/15 (55%) control participants (33% female, aged 26 [21-38] years). The CF-Hypo[+] group versus the control-...Continue Reading

References

Jun 1, 1971·Diabetes·Y JungT S Danowski
Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·C E MillaA Moran
Dec 20, 2000·American Journal of Physiology. Endocrinology and Metabolism·G ToffoloC Cobelli
May 11, 2002·IEEE Transactions on Bio-medical Engineering·Chiara Dalla ManClaudio Cobelli
May 5, 2005·The Journal of Pediatrics·B C MarshallW J Morgan
Feb 27, 2007·European Journal of Endocrinology·A BattezzatiC Colombo
Jun 21, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ray C Boston, Peter J Moate
Jan 26, 2010·The Journal of Clinical Endocrinology and Metabolism·Michael R RickelsAli Naji
Mar 6, 2010·Pediatric Diabetes·Katie Larson OdeAntoinette Moran
Sep 3, 2010·Diabetes·Benjamin A Cooperberg, Philip E Cryer
Jul 25, 2013·Diabetes Care·Irl B HirschMoira L Aitken
Dec 24, 2013·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·A LeclercqL Kessler
Dec 6, 2014·American Journal of Respiratory and Critical Care Medicine·Connor LewisAntoinette Moran
Jun 19, 2015·Pediatric Pulmonology·Saba SheikhAndrea Kelly
Mar 31, 2016·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·N ArmaghanianK S Steinbeck
Nov 23, 2016·Pediatric Diabetes·Belma HalilogluAbdullah Bereket
Apr 24, 2018·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Lisa A MannikAnne L Stephenson
Jun 30, 2018·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Amir Moheet, Katie Larson Ode
Aug 14, 2019·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Marissa J KilbergAndrea Kelly

❮ Previous
Next ❯

Citations

Aug 5, 2021·Clinical Medicine Insights. Endocrinology and Diabetes·Efraim WestholmLena Eliasson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
Marissa J KilbergAndrea Kelly
Obstetrics and Gynecology Clinics of North America
G Pourmotabbed, A E Kitabchi
© 2021 Meta ULC. All rights reserved