Abstract
Hypoglycemia is associated with cardiovascular diseases, increased risk of death. Therefore, it is important to avoid hypoglycemia. The aim of this study was to characterize hypoglycemia according to glycated hemoglobin (HbA1c) level and determine the contributing factors in type 2 diabetes mellitus (T2DM), using continuous glucose monitoring (CGM). T2DM patients (n = 293) receiving inpatient care were divided into five groups according to HbA1c level on admission (Group 1: ≥ 6 to < 7%, Group 2: ≥ 7 to < 8%, Group 3: ≥ 8 to < 9%, Group 4: ≥ 9 to < 10%, and Group 5: ≥ 10%). The frequency of hypoglycemia and factors associated with hypoglycemia were analyzed. Hypoglycemia occurred in 15 patients (5.1%), including 4 (8%), 4 (6%), and 7 (10%) patients of Groups 1, 2, and 3, respectively, but in none of groups 4 and 5. Patients with hypoglycemia of Groups 1 had low insulin secretion and were high among insulin users, those of Groups 2 had low homeostasis model assessment of insulin resistance (HOMA-IR). Those of Group 2 and 3 had significantly lower mean blood glucose levels, those of Group 3 only had significantly lower maximum blood glucose level and percentage of AUC > 180 mg/dL. In any of the HbA1c groups, variations in blood gl...Continue Reading
References
Jul 24, 2001·Archives of Internal Medicine·C D MillerI M El-Kebbi
Mar 29, 2003·Diabetes Care·Graham P LeeseUNKNOWN DARTS/MEMO Collaboration
Oct 28, 2003·Diabetes·Michael S BoyneChristopher D Saudek
Sep 14, 2007·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·K K WeberR Riel
Jun 10, 2008·The New England Journal of Medicine·Anushka PatelFlorence Travert
Dec 18, 2008·The Journal of Clinical Endocrinology and Metabolism·Philip E CryerUNKNOWN Endocrine Society
Jan 12, 2010·BMJ : British Medical Journal·Denise E BondsMary Ellen Sweeney
Jan 12, 2010·BMJ : British Medical Journal·Michael E MillerUNKNOWN ACCORD Investigators
Mar 2, 2010·Internal Medicine·Yasuyoshi ShikamaSoroku Yagihashi
Oct 12, 2010·The New England Journal of Medicine·Sophia ZoungasUNKNOWN ADVANCE Collaborative Group
Apr 5, 2011·Diabetes Technology & Therapeutics·Aya MorimotoKazunori Utsunomiya
Jun 16, 2012·Diabetes Care·Rozalina G McCoySteven A Smith
Sep 8, 2012·Diabetes Technology & Therapeutics·David Rodbard
Aug 1, 2013·Diabetes Care·Kasia J LipskaAndrew J Karter
Oct 19, 2010·Journal of Diabetes Investigation·Yutaka SeinoKohjiro Ueki
Oct 16, 2014·Diabetes·Harumi TakahashiSusumu Seino
Apr 25, 2015·Biomedical Engineering Online·Gábor MaricsPéter Tóth-Heyn
Apr 29, 2015·Journal of Diabetes Science and Technology·Richa Redhu GehlautJay H Shubrook
Oct 16, 2015·Diabetes Care·Virginia BellidoGuillermo E Umpierrez
May 5, 2016·BMJ : British Medical Journal·Francesco SalvoAntoine Pariente
Jun 21, 2016·Diabetes Research and Clinical Practice·Yi-Jing Sheen, Wayne H H Sheu