Hypoglycemia in patients with type 2 diabetes treated with oral antihyperglycemic agents detected by continuous glucose monitoring: a multi-center prospective observational study in Croatia

BMC Endocrine Disorders
Maja Baretić, Valeria Bralić Lang

Abstract

Hypoglycemia in type 2 diabetes mellitus (T2DM) is still unsolved issue. The aim of this study was to investigate hypoglycemia in T2DM in participants treated with oral antihyperglycemic agents using different glucose cut-off values and to explore influence of different therapies. This multi-center prospective observational study included participant with T2DM from primary care offices across Croatia treated with antihyperglycemic agents who were monitored using professional continuous glucose monitoring (CGM) device (iPro™2). Hypoglycemia was defined as at least 1% of the monitored period spent in the hypoglycemic range and/or area under the curve of glycemia registered ever under the defined cut-off value. The higher upper limit of blood glucose cut-off value was 3.9 mmol/L (70 mg/dL) and the lower one 3.0 mmol/L (54 mg/dL). Study included 94 participants. Median hemoglobin A1C levels, age, T2DM duration, body mass index, and CGM use duration were 7 (5.8-11.5) %, 65 (40-86) years, 7 (1-36) years, 30.4 (21.3-41.5) kg/m2 and 6 (1-7) days, respectively. Fifty participants were treated with sulfonylurea, primarily gliclazide (84%). The percentage of participant with hypoglycemia based on the higher cut-off value was 42.6% vs. 16%...Continue Reading

Associated Clinical Trials

Aug 17, 2017·Valerija Bralic Lang

References

Jul 24, 2001·Archives of Internal Medicine·C D MillerI M El-Kebbi
Apr 25, 2009·Diabetes Care·Jian ZhouWeiping Jia
Apr 29, 2015·Journal of Diabetes Science and Technology·Richa Redhu GehlautJay H Shubrook
Jul 25, 2015·Diabetes Care·UNKNOWN International Hypoglycaemia Study Group
Jul 19, 2016·British Journal of Clinical Pharmacology·Stig Ejdrup Andersen, Mikkel Christensen
Nov 4, 2016·Journal of Diabetes Science and Technology·Peter van DijkKornelis J J van Hateren
Nov 23, 2017·Diabetes Care·Thomas DanneMoshe Phillip
Feb 12, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Alan J GarberGuillermo E Umpierrez

❮ Previous
Next ❯

Citations

Jun 13, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·George GrunbergerJeff Unger

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT03253237

Software Mentioned

CareLink iPro

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Related Papers

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Etie MoghissiRobin Cammarota Devine
© 2021 Meta ULC. All rights reserved