Abstract
Hypoglycemia in type 2 diabetes mellitus (T2DM) is still unsolved issue. The aim of this study was to investigate hypoglycemia in T2DM in participants treated with oral antihyperglycemic agents using different glucose cut-off values and to explore influence of different therapies. This multi-center prospective observational study included participant with T2DM from primary care offices across Croatia treated with antihyperglycemic agents who were monitored using professional continuous glucose monitoring (CGM) device (iPro™2). Hypoglycemia was defined as at least 1% of the monitored period spent in the hypoglycemic range and/or area under the curve of glycemia registered ever under the defined cut-off value. The higher upper limit of blood glucose cut-off value was 3.9 mmol/L (70 mg/dL) and the lower one 3.0 mmol/L (54 mg/dL). Study included 94 participants. Median hemoglobin A1C levels, age, T2DM duration, body mass index, and CGM use duration were 7 (5.8-11.5) %, 65 (40-86) years, 7 (1-36) years, 30.4 (21.3-41.5) kg/m2 and 6 (1-7) days, respectively. Fifty participants were treated with sulfonylurea, primarily gliclazide (84%). The percentage of participant with hypoglycemia based on the higher cut-off value was 42.6% vs. 16%...Continue Reading
References
Mar 1, 1989·Diabetes Care·A M JenningsJ D Ward
May 13, 1995·Lancet·R M HeringsA Porsius
Jul 24, 2001·Archives of Internal Medicine·C D MillerI M El-Kebbi
Oct 27, 2001·Diabetes Care·B C TurnerD A Cavan
Nov 25, 2005·Diabetes Care·Nicola N Zammitt, Brian M Frier
Jul 12, 2007·The American Journal of Cardiology·David C GoffUNKNOWN ACCORD Study Group
Nov 24, 2007·Diabetes Technology & Therapeutics·Reinhard ZickUNKNOWN SAFIR Study Group
Apr 25, 2009·Diabetes Care·Jian ZhouWeiping Jia
Oct 20, 2009·Diabetes Care·UNKNOWN Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group
Mar 11, 2010·Diabetes Care·Larry A FoxDongyuan Xing
Dec 1, 2010·Diabetes Care·Sheri R ColbergUNKNOWN American Diabetes Association
Jul 1, 2011·Diabetes Technology & Therapeutics·Nathan R HillDavid R Matthews
Aug 1, 2013·Diabetes Care·Kasia J LipskaAndrew J Karter
Apr 29, 2015·Journal of Diabetes Science and Technology·Richa Redhu GehlautJay H Shubrook
May 25, 2015·Diabetes Research and Clinical Practice·Jean Claude MbanyaIlhan Satman
Jul 25, 2015·Diabetes Care·UNKNOWN International Hypoglycaemia Study Group
Aug 10, 2015·Canadian Journal of Diabetes·Marcos Pazos-CouseloFelipe Casanueva
May 11, 2016·Diabetes, Obesity & Metabolism·K KhuntiUNKNOWN HAT Investigator Group
Jul 15, 2016·BMJ : British Medical Journal·Judith van DalemAndrea M Burden
Jul 19, 2016·British Journal of Clinical Pharmacology·Stig Ejdrup Andersen, Mikkel Christensen
Aug 30, 2016·Diabetes & Metabolic Syndrome·Vadim V Klimontov, Natalia E Myakina
Nov 4, 2016·Journal of Diabetes Science and Technology·Peter van DijkKornelis J J van Hateren
Nov 23, 2017·Diabetes Care·Thomas DanneMoshe Phillip
Feb 12, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Alan J GarberGuillermo E Umpierrez