Hypoglycemia induced changes in cholinergic receptor expression in the cerebellum of diabetic rats.

Journal of Biomedical Science
Sherin AntonyC S Paulose

Abstract

Glucose homeostasis in humans is an important factor for the functioning of nervous system. Hypoglycemia and hyperglycemia is found to be associated with central and peripheral nerve system dysfunction. Changes in acetylcholine receptors have been implicated in the pathophysiology of many major diseases of the central nervous system (CNS). In the present study we showed the effects of insulin induced hypoglycemia and streptozotocin induced diabetes on the cerebellar cholinergic receptors, GLUT3 and muscle cholinergic activity. Results showed enhanced binding parameters and gene expression of Muscarinic M1, M3 receptor subtypes in cerebellum of diabetic (D) and hypoglycemic group (D + IIH and C + IIH). alpha7nAchR gene expression showed a significant upregulation in diabetic group and showed further upregulated expression in both D + IIH and C + IIH group. AchE expression significantly upregulated in hypoglycemic and diabetic group. ChAT showed downregulation and GLUT3 expression showed a significant upregulation in D + IIH and C + IIH and diabetic group. AchE activity enhanced in the muscle of hypoglycemic and diabetic rats. Our studies demonstrated a functional disturbance in the neuronal glucose transporter GLUT3 in the cereb...Continue Reading

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Citations

Jun 22, 2012·International Journal of Pediatric Endocrinology·Kimberly E LeheckaRubina A Heptulla
Nov 6, 2013·Journal of Signal Transduction·Alexander O Shpakov, Kira V Derkach
Apr 11, 2018·Molecular Neurobiology·Ashish K Rehni, Kunjan R Dave
Aug 15, 2014·American Journal of Physiology. Endocrinology and Metabolism·Edmund F LaGammaBistra B Nankova
Aug 26, 2016·Reviews in the Neurosciences·Changzheng ZhangTifei Yuan
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Dec 15, 2016·Turkish Journal of Medical Sciences·Nuriye Güzin ÖzdemİrAdem Yılmaz

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Methods Mentioned

BETA
PCR
Esterase Assay

Software Mentioned

GraphPad Instat

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