Hypoglycemia Prevention and User Acceptance of an Insulin Pump System with Predictive Low Glucose Management

Diabetes Technology & Therapeutics
Pratik ChoudharyJohn Shin

Abstract

The MiniMed 640G sensor-augmented insulin pump system (Medtronic, Inc., Northridge, CA) can automatically suspend insulin delivery in advance of predicted hypoglycemia and restart it upon recovery. The aims of this analysis were to determine the rate at which predicted hypoglycemia was avoided with this strategy, as well as to assess user acceptance of the system and its insulin management features. Forty subjects with type 1 diabetes used the system for 4 weeks. We retrospectively evaluated performance of the system, using downloaded pump and sensor data, and evaluated user acceptance via questionnaires. There were 2,322 suspend before low events (2.1 per subject-day). The mean (± SD) duration of pump suspension events was 56.4 ± 9.6 min, and the mean subsequent sensor glucose (SG) nadir was 71.8 ± 5.2 mg/dL. SG values following 1,930 (83.1%) of the predictive suspensions did not reach the preset low limit. Nadir SG values of ≤50 and ≤60 mg/dL were seen in 207 (8.9%) and 356 (15.3%) of the predictive suspensions, respectively. Blood glucose (BG) and SG values before and during the study were comparable (P > 0.05). The mean absolute relative difference between paired SG and BG values was 10.9 ± 13.8%. Subjects felt confident us...Continue Reading

References

Jun 25, 2013·The New England Journal of Medicine·Richard M BergenstalUNKNOWN ASPIRE In-Home Study Group
May 9, 2014·Diabetes Care·David M MaahsUNKNOWN In Home Closed Loop Study Group

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Citations

Jul 2, 2016·Diabetologia·Hood Thabit, Roman Hovorka
Jul 6, 2016·Diabetes Technology & Therapeutics·Pratik Choudhary
Oct 18, 2016·Diabetes Technology & Therapeutics·Alex ZhongFrancine R Kaufman
Feb 14, 2017·Diabetes Technology & Therapeutics·Bruce W Bode, Tadej Battelino
Apr 21, 2017·Diabetes Technology & Therapeutics·Jordan E Pinsker, Eyal Dassau
Apr 21, 2017·Pediatric Diabetes·Peter AdolfssonRagnar Hanas
May 19, 2017·Diabetes Technology & Therapeutics·Lenka PetruzelkovaBarbora Obermannova
May 23, 2017·Diabetes Technology & Therapeutics·Oliver SchnellPhilip Home
May 26, 2017·Diabetes Technology & Therapeutics·David Slattery, Pratik Choudhary
May 26, 2017·Diabetes Technology & Therapeutics·Ramzi A Ajjan
Jul 13, 2017·Diabetes Technology & Therapeutics·Mark P ChristiansenFrancine R Kaufman
May 14, 2016·Journal of Diabetes Science and Technology·Bartłomiej MatejkoTomasz Klupa
Aug 1, 2018·Diabetes Technology & Therapeutics·Robert H SloverFrancine R Kaufman
Nov 10, 2017·Endocrinology, Diabetes & Metabolism Case Reports·E S ScottR J Clifton-Bligh
Aug 29, 2018·Journal of Diabetes·Robert A Vigersky
Dec 27, 2018·Diabetes Technology & Therapeutics·Mary B AbrahamUNKNOWN PLGM Study Group
Aug 19, 2017·Nature Reviews. Endocrinology·John C Pickup
May 30, 2019·Diabetes Technology & Therapeutics·Laurel H MesserGregory P Forlenza
Mar 6, 2018·Diabetes & Metabolism Journal·Ahmed IqbalSimon R Heller
Mar 12, 2020·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Jordan E PinskerSteph Habif
Mar 7, 2017·Journal of Diabetes Science and Technology·Isabelle SteineckSigne Schmidt
Jul 6, 2019·Endocrine Reviews·Rayhan A LalBruce Buckingham
May 10, 2016·Diabetes Technology & Therapeutics·H Peter Chase
Mar 16, 2017·Current Diabetes Reports·Nantia Othonos, Pratik Choudhary
Mar 7, 2017·Journal of Diabetes Science and Technology·Ewa PańkowskaKarolina Mazurczak
Feb 22, 2017·Diabetes Technology & Therapeutics·Bruce A BuckinghamFrancine R Kaufman
Oct 10, 2018·Diabetes Technology & Therapeutics·Michael A WoodFrancine R Kaufman
Sep 25, 2019·Diabetes Care·Rayhan A LalDarrell M Wilson

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