Hypoglycemic activity of Ziziphus mauritiana aqueous ethanol seed extract in alloxan-induced diabetic mice

Pharmaceutical Biology
Aruna Bhatia, Tulika Mishra

Abstract

Ziziphus mauritiana Lamk. (Rhamnaceae) is a fruit tree that has been used as folkloric medicine for many ailments and diseases. In the present study, the hypoglycemic effect of seed extract of Ziziphus mauritiana in alloxan-induced diabetic mice was assessed. Seed extract was administered orally at doses of 100, 400, and 800 mg/kg body weight (bw) and also in combination with glyburide (800 mg/kg seed extract and 10 mg/kg glyburide) to different groups of mice (normal and alloxan-treated diabetic mice). Their blood glucose level (in acute and sub-acute study), body weight, and mortality rate were monitored. Oral glucose tolerance test (OGTT) was also performed. Oral administration of extract alone or in combination with glyburide reduced the blood glucose level in all the diabetic mice after acute and sub-acute (28 days) administration. Administration of the extract reduced the weight loss and mortality rate during the sub-acute study. The results of blood glucose level, loss in body weight, and mortality rate were more pronounced in the group treated with combination (800 mg/kg seed extract and 10 mg/kg glyburide). The extract also augmented the glucose tolerance in both normal and diabetic mice. These results suggest that the...Continue Reading

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Citations

Jul 19, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Aye Moh Moh SanWandee Gritsanapan
Oct 19, 2010·Evidence-based Complementary and Alternative Medicine : ECAM·Tulika MishraAruna Bhatia
Jun 25, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Hock Eng KhooAmin Ismail
Jul 28, 2016·Journal of Ethnopharmacology·Geetha Krishnan Gopalakrishna PillaiRam A Vishwakarma
Mar 18, 2017·Journal of Complementary & Integrative Medicine·Oluwafemi Adeleke OjoOluwatosin Adeyonu
Dec 17, 2019·Environmental Science and Pollution Research International·Rafa S AlmeerAhmed E Abdel Moneim
May 1, 2021·Plants·Md Masudur RahmanJesus Simal-Gandara

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