Hypoglycemic and hypolipidemic effect of S-allyl-cysteine sulfoxide (alliin) in DIO mice

Scientific Reports
Baiqiang ZhaiYunbo Luo

Abstract

Alliin (S-allyl cysteine sulfoxide) is a bioactive sulfoxide compound derived from garlic. To evaluate the preventive effect of alliin against metabolic risk factors in diet induced obese (DIO) mice, we treated the C57BL/6J DIO mice with drinking water with or without alliin (0.1 mg/ml) for 8 weeks. Results showed that alliin had no significant effect on the body weight, adiposity or energy balance. However, alliin treatment enhanced glucose homeostasis, increased insulin sensitivity and improved the lipid profile in the DIO mice. This was, at least partly, attributable to alliin induced modulation of the intestinal microbiota composition, typically decreased Lachnospiraceae and increased Ruminococcaceae. From above, we conclude that alliin has nutraceutical or even medicinal potential in prevention of diabetes and lipid metabolic disorders.

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Feb 2, 2020·Gut Microbes·Aneseh Adeshirlarijaney, Andrew T Gewirtz
Jan 12, 2020·Current Hypertension Reports·Isabel QuesadaClaudia Castro
Mar 4, 2020·Nutrients·Marina A Sánchez-SánchezRocío Ivette López-Roa
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Methods Mentioned

BETA
PCR

Software Mentioned

ANOSIM
SPSS Statistics
LEfSe
Uparse
PAST

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