Hypoglycemic effect of a hot-water extract from defatted sesame (Sesamum indicum L.) seed on the blood glucose level in genetically diabetic KK-Ay mice

Bioscience, Biotechnology, and Biochemistry
H TakeuchiP He

Abstract

Genetically diabetic (type II) KK-Ay mice, male and 5 weeks of age, were divided into one group of 12 mice that were fed on a basal (BAS) diet and three groups of 6 mice each that were fed on the test diets for 4 weeks. Each test diet contained 4.0% of the hot-water extract (HES) from defatted sesame (Sesamum indicum L.) seed, 1.4% of the water eluent fraction (WFH) of HES or 0.7% of the methanol eluent fraction (MFH) of HES from a glass column packed with HP-20 resin. At the end of the feeding period, the BAS group was divided into the MAL and MALH groups which were respectively force-fed with 1 ml per mouse of a 20% maltose solution in water with or without 4.0% HES. The plasma glucose concentration and amount of urinary excreted glucose were lower from the HES and MFH diets than from the BAS and WFH diets. The levels of plasma glucose and serum insulin were lower in the MALH group than in the MAL group. These results indicate that HES and MFH had a reductive effect on the plasma glucose concentration of KK-Ay mice, and this effect is suggested to have been caused by the delayed glucose absorption.

Citations

Mar 8, 2008·Bioscience, Biotechnology, and Biochemistry·Kazunari TanakaIkuo Ikeda
Oct 19, 2007·Critical Reviews in Food Science and Nutrition·Mitsuo Namiki
Sep 11, 2012·Journal of Clinical Biochemistry and Nutrition·Kayoko HondaNaotaka Hashizume
Jan 18, 2005·Journal of Ethnopharmacology·Atul N Jadhav, K K Bhutani
Sep 4, 2014·Asian Pacific Journal of Tropical Biomedicine·Repon Kumer SahaPriyanka Roy

Related Concepts

Blood Glucose
Diabetes Mellitus, Non-Insulin-Dependent
Glycosuria
Hypoglycemic Effect
Novolin
Maltose
Plant Extracts
Pedaliaceae

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