PMID: 11320754Apr 26, 2001Paper

Hypoglycemic effect of sodium salt of monoketocholic acid in diabetic rats

Medicinski pregled
A Tenji

Abstract

In recent years experiments have showed that synthetic derivatives of bile acid affect blood glucose level. The aim of this work was to study the influence of sodium salt of monoketcholanate (MKH) on blood glucose level in rats with induced diabetes. Diabetes was induced with streptozotocin applied intraperitoneally in a dose of 70 mg/kg body weight. The experiments were carried out in white laboratory rats. They were divided in two groups: group A--rats with induced diabetes (n = 10) and group B--rats with normal blood glucose level (control group, n = 10). Both groups of animals were anesthetized with urethan applied intraperitoneally in a dose of 0.75 g/kg body weight and were divided in two subgroups. The subgroups, one of each group of animals, were treated intranasally with 2% solution of MHK, in dose of 0.2 ml/kg body weight. The other two subgroups (control subgroups) received saline solution intranasally in a dose of 0.2 ml/kg body weight. Blood was taken periodically from the tail vein and blood glucose level was determined at 0, 15, 30, 45, 60, 90, 120 and 180-th minutes after treatment. In the group of rats with normal blood glucose level (group B) MKH did not show any statistically important changes in blood glucos...Continue Reading

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