Hypoglycemic effect of the water extract of Piper sarmentosum in rats

Journal of Ethnopharmacology
P PeungvichaS Kadota

Abstract

The hypoglycemic effect of the water extract of the whole plant of Piper sarmentosum Roxb. (Piperaceae, Thai name: Chaplu) was examined in normal and streptozotocin-diabetic rats. In an oral glucose tolerance test, a single oral administration of the water extract at doses of 0.125 and 0.25 g/kg significantly lowered the plasma glucose level in the normal rats. A reference drug, glibenclamide, at a dose of 5 mg/kg (per os, p.o.) also showed a significant hypoglycemic effect in the normal rats. In contrast, a single oral administration of the water extract at these doses and glibenclamide did not significantly lower the plasma glucose level in the diabetic rats. However, the repeated oral administration of the water extract at a dose of 0.125 g/kg for 7 days produced a significant hypoglycemic effect in the diabetic rats. Glibenclamide (5 mg/kg, p.o.) also caused significant hypoglycemia in the diabetic rats. These results demonstrated that the water extract of whole plant of Piper sarmentosum has a hypoglycemic effect in rats.

References

Feb 28, 1991·The New England Journal of Medicine·J M Astrachan
Feb 1, 1985·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·R D Bruce
Jan 1, 1960·Scandinavian Journal of Clinical and Laboratory Investigation·E RAABO, T C TERKILDSEN

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Citations

May 15, 2002·Journal of Ethnopharmacology·Jaouad El Hilaly, Badiâa Lyoussi
May 24, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Chutwadee KrisanapunSeung Joon Baek
Sep 14, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Mohd Azri Abd JalilNorliza Muhammad
Apr 19, 2011·BMC Complementary and Alternative Medicine·Azizah UgusmanNor Anita Megat Mohd Nordin
Feb 19, 2013·BMC Complementary and Alternative Medicine·Shaik Abdul NabiChippada Appa Rao
Mar 5, 2009·Cancer Cell International·Shahrul Hisham Zainal AriffinRohaya Megat Abdul Wahab
Jun 1, 2010·Diabetes Research and Clinical Practice·K NoiphaP Ninla-Aesong
Jul 6, 2004·Journal of Ethnopharmacology·Thitima RukachaisirikulApichart Suksamrarn
Jul 15, 2006·Journal of Ethnopharmacology·G KumarM Rajasekara Pandian
Sep 1, 2015·Asian Pacific Journal of Tropical Medicine·Nor Adlin YusoffMohd Zaini Asmawi
Jan 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Zar Chi ThentZaiton Zakaria
Aug 19, 2011·Pharmaceutical Biology·Chao-Ming ChuangRobert Y Peng
Jul 26, 2012·Toxicology Mechanisms and Methods·Thulasingam SenthilkumarNatarajan Ashokkumar
May 6, 2010·Journal of Zhejiang University. Science. B·Abdul Hamid HafizahAbdullah Mahdy Zaleha
Sep 23, 2009·Evidence-based Complementary and Alternative Medicine : ECAM·Khalid HussainPazillah Ibrahim
Nov 15, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Maizura Mohd ZainudinFaizah Othman
Jul 28, 2016·Journal of Ethnopharmacology·Geetha Krishnan Gopalakrishna PillaiRam A Vishwakarma
Sep 16, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Poonam ShokeenVibha Tandon
Nov 18, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Siti Fadziyah Mohamad AsriFarihah Suhaimi
Mar 21, 2006·Revista Do Instituto De Medicina Tropical De São Paulo·Wej ChoochoteBenjawan Pitasawat
Aug 2, 2005·Journal of Ethnopharmacology·L S R ArambewelaW D Ratnasooriya
Mar 20, 2002·Addiction Biology·B J Boucher, N Mannan
Apr 11, 2012·Pharmaceutical Biology·Khalid HussainAmirin Sadikun
Dec 13, 2019·Journal of Ethnobiology and Ethnomedicine·Fengke LinChunlin Long
Aug 4, 2020·Journal of Asian Natural Products Research·Duc Minh Nguyen HuuThi Lien Thuong Nguyen
Sep 6, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Fatimatuzzahra Hashim FauzyTaher F T Elshami
Oct 23, 2020·International Journal of Molecular Sciences·Siti Fadziyah Mohamad AsriElvy Suhana Mohd Ramli
Jul 2, 2021·Frontiers in Pharmacology·Muhd Fakh Rur Razi Md SallehAzizah Ugusman

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