Hypoglycemic potency of novel trivalent chromium in hyperglycemic insulin-deficient rats

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
Bogusław MachalińskiElzbieta Dabkowska

Abstract

Two sources of chromium III, "chromium 454" and "chromium picolinate," were tested in insulin-deficient Streptozocin-treated diabetic rats. This model was selected in order to evaluate the possibility of any hypoglycemic potency of chromium in a relative absence of blood insulin concentration. Three weeks of the treatment with CRC454 and CrP resulted in a 38% and 11% reduction of blood glucose levels, respectively. Body weight gains were equally improved by both treatments. Blood levels of CK, ALT and AST were significantly reduced by CRC454 and CrP. These results might suggest that any hypoglycemic effect of trivalent chromium under insulin-deficient conditions could be largely dependent upon the type of chromium agent and associated characteristics such as solubility and bioavalibility. In contrast, improvement of body weight gains and blood levels of CK, AST and ALT seems to be less dependent on the type of chromium compound under these experimental conditions. In conclusion, CRC454 showed significant reduction of hyperglycemia under insulin-deficient conditions.

Citations

Jul 22, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·John B Vincent
Nov 6, 2012·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Bhuvaneshwari SundaramRajat Sandhir
Aug 21, 2010·Life Sciences·Min J KwonJeong H Park
Jul 21, 2009·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Ayhan DogukanKazim Sahin
Sep 24, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ewelina Król, Zbigniew Krejpcio
Mar 1, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Fang LiLiuqing Yang
Mar 8, 2020·Biological Trace Element Research·Mikhail Yu KarganovAnatoly V Skalny

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