Hypoglycemic potential of nateglinide versus glyburide in patients with type 2 diabetes mellitus

Metabolism: Clinical and Experimental
V A FonsecaJ E Gerich

Abstract

Antidiabetic agents that augment insulin secretion can cause hypoglycemia. With the current trend toward early and aggressive treatment of patients with type 2 diabetes, the hypoglycemic potential of insulinotropic agents is of concern. This study aimed to compare the propensity of the "glinide," nateglinide, and the sulfonylurea (SU), glyburide, to elicit hypoglycemia in type 2 diabetic patients with moderately elevated fasting plasma glucose (FPG). Hyperglycemic clamps (target plasma glucose = 11.1 mmol/L) were initiated, and 30 minutes later patients received a single oral dose of nateglinide (120 mg, n = 15) or glyburide (10 mg, n = 12) in a double-blind fashion. At the end of the 2-hour clamp when the glucose infusion was terminated, plasma glucose and insulin levels were measured for 4 additional hours. The minimum plasma glucose level achieved after terminating the glucose infusion (glucose nadir) was used as an index of hypoglycemic potential. The mean (+/-SEM) glucose nadir was significantly lower in patients given glyburide (3.3 +/- 0.2 mmol/L) versus nateglinide (4.4 +/- 0.3 mmol/L, P = .025). Confirmed hypoglycemia (plasma glucose < or = 2.8 mmol/L) occurred in 2 of 12 patients given glyburide and in none of those g...Continue Reading

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Citations

Nov 21, 2007·Annals of Emergency Medicine·Daniel K Sherk, Sean M Bryant
Sep 18, 2012·Metabolism: Clinical and Experimental·Jian LuoZhiguang Guo
Sep 16, 2009·The American Journal of Emergency Medicine·Charles J Fasano, Adam K Rowden
May 8, 2007·Emergency Medicine Clinics of North America·Adam K Rowden, Charles J Fasano
Sep 24, 2005·International Journal of Clinical Practice·I W Campbell
Jan 8, 2009·Journal of Clinical Pharmacy and Therapeutics·G DerosaA F G Cicero
Jan 31, 2008·Diabetes/metabolism Research and Reviews·Patrick J Boyle, John Zrebiec

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