Hypoglycemic potential of selenium nanoparticles capped with polyvinyl-pyrrolidone in streptozotocin-induced experimental diabetes in rats

Heliyon
Ola M El-BoradyAhmed E Abdel Moneim

Abstract

This study was aimed to evaluate the efficacy of synthesized selenium nanoparticles (SeNPs) capped with glucose and polyvinyl-pyrrolidone (PVP) on the hyperglycemia and prooxidants/antioxidants imbalance present in model streptozotocin (STZ)-induced diabetic rats. SeNPs were synthesized and characterized. Twenty-four albino male rats were grouped into four different groups. After the rats were induced to have type 2 diabetes by STZ, the SeNPs-treated groups received a dose of 0.5 mg/ml of SeNPs for seven days. Plasma glucose and insulin levels, pancreatic insulin expression, the levels of lipid peroxidation (LPO), nitric oxide (NO), glutathione peroxidase (GPx) and glutathione (GSH) were evaluated. TEM images revealed the formation of semispherical particles with average size between 40 and 50 nm. SeNPs administration successfully reduced the hyperglycemia, raised the levels of insulin in both the pancreas and the plasma and restored the damaged pancreatic tissue. SeNPs also showed enhancement of the elimination of the diabetes-induced oxidative stress injuries by decreasing the pancreatic LPO and NO levels. Furthermore, the activities of the antioxidant enzyme GPx and GSH levels of the diabetic rats were increased. In conclusi...Continue Reading

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Citations

Jul 9, 2020·Environmental Science and Pollution Research International·Tarfa Albrahim
Jun 15, 2021·Advanced Healthcare Materials·Cláudio FerroHélder A Santos
Jul 20, 2021·Critical Reviews in Food Science and Nutrition·Jingpeng Yang, Hong Yang
Jan 28, 2022·Environmental Science and Pollution Research International·Mohamed S OthmanAhmed E Abdel Moneim

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Methods Mentioned

BETA
ELISA
biopsy
PCR

Software Mentioned

Primer
SPSS
- Blast

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