PMID: 2500019Jun 1, 1989Paper

Hypogonadism following long-term treatment with diethylstilbestrol

The American Journal of the Medical Sciences
J WortsmanS J Winters

Abstract

The authors describe the abnormalities of gonadal function developing in a patient with prostate cancer who had received estrogen therapy continuously for 6 years. The pretreatment prostate biopsy showed well developed acini consistent with normal androgenization and adenocarcinoma. Twelve years later, 6 years after discontinuation of estrogen treatment, the patient presented with severe hypogonadism, gynecomastia, and primary hypothyroidism. Testicular biopsies showed ghosts of seminiferous tubules with absence of Leydig cells, and prostatic biopsies showed atrophic acini without evidence of malignancy. Despite undetectable serum testosterone levels, serum gonadotropins were inappropriately normal and responded minimally to gonadotropin-releasing hormone (GnRH) administration. Replacement therapy with levothyroxine did not correct gonadal dysfunction. Thus, prolonged estrogen therapy may result in irreversible testicular destruction and loss of the feed-back response of the hypothalamic pituitary gonadal axis.

References

Feb 1, 1978·The Journal of Clinical Endocrinology and Metabolism·S T BigosF Maloof
Sep 1, 1975·Journal of Gerontology·M MuggeoG Crepaldi
Jan 1, 1986·Mayo Clinic Proceedings·C F Abboud
Feb 1, 1987·The American Journal of Medicine·J WortsmanM L Dufau
Sep 1, 1987·The Journal of Clinical Investigation·J D Veldhuis, M L Dufau
Apr 1, 1987·The Journal of Clinical Endocrinology and Metabolism·P MineurR De Hertogh
Jan 1, 1973·The Journal of Clinical Endocrinology and Metabolism·R M BoyarL Hellman
May 1, 1973·The Journal of Clinical Endocrinology and Metabolism·R J Sherins, D L Loriaux
May 1, 1981·The Journal of Clinical Investigation·D RudmanR P Bain
Jan 1, 1980·Endocrinology·N R KallaD L Loriaux

❮ Previous
Next ❯

Citations

May 1, 2010·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·A W F T TooriansR L A P Hoogenboom
Oct 12, 2005·The Journal of Urology·Adrian Dobs, Malcolm J M Darkes
Sep 11, 2010·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Jennifer S Ten KulveWillem de Ronde

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
M R FieldenT R Zacharewski
Reproduction : the Official Journal of the Society for the Study of Fertility
Géraldine DelbèsRené Habert
© 2022 Meta ULC. All rights reserved