PMID: 8963392Dec 1, 1995Paper

Hypogonadism is not related to the etiology of liver cirrhosis

Journal of Gastroenterology
S KaymakoğluS Yalçin

Abstract

We investigated the clinical and laboratory findings of hypogonadism and feminization in male patients with viral or alcoholic cirrhosis to determine whether chronic liver disease plays a primary role in the development of sexual dysfunction and hormonal changes. Two groups of male patients with liver cirrhosis (23 alcoholic, 33 viral) age- and Child's grade-matched, and 20 age-matched healthy men, as a control group, were included in this study. Clinical signs of hypogonadism and feminization were examined in the cirrhotic patients. Follicle-stimulating hormone, luteinizing hormone, prolactin, testosterone, free testosterone, estradiol, androstenedione, dehydroepiandrosterone sulfate, and sex hormone-binding globulin were estimated in all groups. Seminal fluid was also analyzed in 7 alcoholic and 15 viral cirrhotics. Serum levels of estradiol, androstenedione, and sex hormone-binding globulin were significantly higher, and free testosterone and dehydroepiandrosterone sulfate levels were significantly lower in both groups of cirrhotics compared with the control group. Child's C patients in both groups of cirrhotics were found to have higher estradiol and lower free testosterone levels than child's A and B patients. Alcoholic an...Continue Reading

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Citations

Jul 29, 2009·Rheumatology International·Ghizlane WariaghliAbdellah El Maghraoui
Apr 25, 2012·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Ashish Kumar
Jan 29, 1999·Endocrinology and Metabolism Clinics of North America·H W Baker
Aug 2, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·Peter B LuppaJochen Metzger
Oct 16, 2013·Journal of Bone and Mineral Metabolism·Yumie RheeSe Hwa Kim
Feb 12, 2009·The Journal of Sexual Medicine·Eric HuygheLionel Rostaing
Nov 15, 2011·Clinics and Research in Hepatology and Gastroenterology·Alper YurciOmer Ozbakir
Jun 23, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Harry Wu, Geoffrey C Nguyen
Nov 3, 2015·Best Practice & Research. Clinical Endocrinology & Metabolism·Markus A ThalerPeter B Luppa
Aug 17, 2001·European Journal of Gastroenterology & Hepatology·O W HamerK D Palitzsch
Sep 22, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jane Collier
Sep 26, 2013·Scandinavian Journal of Gastroenterology·Evangelos KalaitzakisEinar Björnsson
Aug 24, 2011·World Journal of Hepatology·Rebecca MitchellConstance L Chik
May 10, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Nanfu DengRuben Hernaez

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