Hypohidrosis during topiramate treatment: a rare and reversible side effect

Pediatric Neurology
Caterina CerminaraPaolo Curatolo

Abstract

Topiramate is an antiepileptic drug with a beneficial clinical effect on various seizure types. Topiramate does not seem to be associated with serious adverse effects and is also well tolerated in pediatric patients. Only few cases of hypohidrosis have been described. This report presents one young patient with complex partial seizures who was medicated with topiramate when she developed fatigue, headache, intermittent hyperthermia, inability to produce sweat secretion, and dryness of the skin. Reduced sweat response was determined using the Wescor Macroduct collection procedure. Topiramate was discontinued, and within 3 weeks a repeat sweat test was completely normal. At that time, clinical signs had also disappeared. Hypohidrosis is an uncommon and reversible side effect reported in association with topiramate therapy. It is rare in patients on monotherapy. Although a definite causal relationship still needs to be established, this side effect might be attributed to an autonomic dysfunction by inhibition of isoenzymes of carbonic anhydrase localized in human eccrine sweat glands.

Citations

Aug 19, 2007·Indian Journal of Pediatrics·Eva L W Fung, Edmund A S Nelson
Jan 3, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Steven C Schachter
Dec 4, 2008·Clinical Neuropharmacology·Lucia MargariMarina de Tommaso
Sep 16, 2008·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Vassiliki SirrouElisabeth Chroni
Mar 3, 2010·CNS Drugs·Dean P Sarco, Blaise F D Bourgeois
May 16, 2013·CNS Drugs·Athanasios Gaitatzis, Josemir W Sander
Dec 3, 2013·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·M Rosich Del CachoC López-Menchero Oliva
Feb 26, 2016·CNS Drugs·Eman BahraniJoseph S Kass
May 23, 2007·Basic & Clinical Pharmacology & Toxicology·Jiyu TianJingchun Wang
May 17, 2008·CNS Neuroscience & Therapeutics·Richard P Shank, Bruce E Maryanoff
Apr 15, 2016·Journal of Medical Case Reports·Lucie CanelMathieu Nendaz
Apr 9, 2008·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·T BoussemartJ-M Bonardi
Jun 7, 2013·Continuum : Lifelong Learning in Neurology·L James Willmore
Sep 7, 2018·BMJ Case Reports·Roopa SiddaiahGavin Graff
Aug 11, 2018·Journal of Addiction Medicine·Ajay ManhapraAlbert J Arias
Jan 26, 2008·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·William P Cheshire, Robert D Fealey
Mar 20, 2010·Headache·Shira Y MarkowitzBrian M Grosberg
Oct 16, 2019·Journal of the American Academy of Dermatology·Jordan RosenGil Yosipovitch
Feb 5, 2021·International Journal of Women's Dermatology·Mary L Williams
Oct 24, 2007·Emergency Medicine Clinics of North America·Michelle D Blumstein, Marla J Friedman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.