Hypoinsulinemic hypoglycemia triggered by liver injury in elderly subjects with low body weight: case reports

Endocrinology, Diabetes & Metabolism Case Reports
Takatoshi AnnoNiro Okimoto

Abstract

Hypoglycemia is induced by many causes, especially over-dose of insulin or oral hypoglycemic agents in diabetic subjects. In such a case, hyperinsulinemic hypoglycemia is usually observed. On the other hand, it is important to classify secondary hypoglycemia and hypoinsulinemic hypoglycemia. Liver injury-induced hypoglycemia is one of the causes of hypoinsulinemic hypoglycemia but rarely observed in clinical practice. Herein, we experienced similar 2 cases of non-diabetic hypoinsulinemic hypoglycemia. Both of them were elderly subjects with low body weight. Furthermore, it is likely that hypoinsulinemic hypoglycemia in both subjects was triggered by severe liver injury, at least in part, due to possible limited liver glycogen store. In elderly subjects with low body weight and/or malnutrition, metabolism in the liver is reduced and glycogen accumulation is decreased. Such alteration brings out acute and marked liver injury, which finally leads to the onset of severe hypoglycemia. It is known that not only liver injury but also multiple organ failure could be induced due to extreme emaciation in subjects. It is likely that in elderly subjects with low body weight and/or malnutrition, multiple organ failure including liver failur...Continue Reading

References

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Sep 27, 2015·The International Journal of Eating Disorders·Mark L NorrisMargaret Sampson

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Citations

Jul 3, 2021·Medical Sciences : Open Access Journal·Sanjay KalraPawan Rawal

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Methods Mentioned

BETA
biopsies

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