Hypokalemia in a patient with pheochromocytoma.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
M S MolisonP J Numann

Abstract

To report the occurrence of hypokalemia in a patient with pheochromocytoma. We present a case report and discuss the possible role of hyperepinephrinemia as a cause of hypokalemia. A patient with pheochromocytoma had hypokalemia associated with vomiting, but hypokalemia recurred after repletion of potassium and cessation of vomiting. She had substantially increased epinephrine concentrations in the plasma and in the subsequently excised pheochromocytoma. Because evidence has shown that infusions of epinephrine induce hypokalemia in normal human subjects, the relationship between serum potassium and plasma epinephrine concentrations in 16 previous patients with pheochromocytoma and 4 patients with primary hyperepinephrinemia was studied. A significant negative correlation was noted. The presence of hypokalemia and its potential role in predisposing to arrhythmias in patients with pheochromocytoma merit further study.

References

Aug 23, 1979·The New England Journal of Medicine·R F SparkL Landsberg
May 1, 1978·Diseases of the Colon and Rectum·M K MattaI T Khubchandani
Jan 1, 1970·European Journal of Pharmacology·F MassaraM Rotunno
May 4, 1984·Science·J Axelrod, T D Reisine
Dec 8, 1983·The New England Journal of Medicine·M J BrownM B Murphy
May 1, 1982·Hypertension·E L BravoD G Vidt
Oct 1, 1982·Metabolism: Clinical and Experimental·W SternheimP J Speller
Jul 1, 1952·The Journal of Clinical Endocrinology and Metabolism·O COPEE F BLAND

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Citations

Jul 14, 2010·Fundamental & Clinical Pharmacology·Torben Clausen
Dec 10, 2013·Journal of Clinical Psychopharmacology·Ewout J Hoorn, Marcel F P van der Poel
Sep 28, 2006·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Aaron R ChidakelAlejandro R Ayala

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