Hypokinesia in Huntington's disease co-occurs with cognitive and global dysfunctioning

Movement Disorders : Official Journal of the Movement Disorder Society
Nanda ReedekerRaymond A C Roos

Abstract

Besides chorea, hypokinesia is an important motor disturbance in Huntington's disease (HD) but its clinical, neuropsychiatric, and cognitive functioning correlates are largely unknown. This cross-sectional study investigates correlates of hypokinesia in HD and its effect on global functioning. Among 150 HD gene carriers, 96 patients were clinically motor manifest. Hypokinesia was assessed using the motor section of the Unified Huntington's Disease Rating Scale and global functioning was measured using the Total Functioning Capacity (TFC) scale. Neuropsychiatric measures included the Apathy Scale and the Composite International Diagnostic Interview for diagnosis of depression. The Mini Mental State Examination (MMSE) and a composite executive cognitive measure were used to assess global and executive cognitive functioning, respectively. Compared with 45 patients with no or mild hypokinesia, 51 patients with moderate to severe hypokinesia showed a significant difference in most clinical and neuropsychiatric variables and had worse cognitive functioning scores. However, using forward logistic regression analysis, poor executive cognitive functioning was the only independent correlate of hypokinesia (OR 7.33; 95% CI: 2.82-19.0; P <...Continue Reading

References

Jan 1, 1979·Neurology·I Shoulson, S Fahn
Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jan 1, 1992·The Journal of Neuropsychiatry and Clinical Neurosciences·S E StarksteinR G Robinson
Jan 1, 1990·Movement Disorders : Official Journal of the Movement Disorder Society·J B PenneyJ Alvir
Nov 1, 1993·Stroke; a Journal of Cerebral Circulation·S E StarksteinR G Robinson
Mar 1, 1993·The Journal of Nervous and Mental Disease·J C RothlindJ Brandt
Mar 1, 1996·Movement Disorders : Official Journal of the Movement Disorder Society
Jul 1, 1996·Movement Disorders : Official Journal of the Movement Disorder Society·J P van VugtR A Roos
Jan 15, 2000·Neurology·R Sánchez-PernauteK L Leenders
Feb 9, 2000·Psychosomatics·A Rosenblatt, I Leroi
Dec 19, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·J KulisevskyJ L Cummings
Mar 9, 2002·The Journal of Neuropsychiatry and Clinical Neurosciences·Jennifer C ThompsonDavid Neary
Aug 10, 2002·Medicine·Anneke Maat-KievitRaymund Roos
Nov 26, 2002·The British Journal of Surgery·T Bates
Oct 2, 2003·Annals of Neurology·Adam RosenblattChristopher A Ross
Feb 18, 2006·Dementia and Geriatric Cognitive Disorders·Sophie BaudicAnne-Catherine Bachoud-Lévi
Jul 13, 2006·Neurology·L Kirsch-DarrowD Bowers
Jan 24, 2007·Lancet·Francis O Walker
Dec 12, 2007·The Journal of Neuropsychiatry and Clinical Neurosciences·E van DuijnR C van der Mast
Dec 22, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·J S PaulsenUNKNOWN Predict-HD Investigators and Coordinators of the Huntington Study Group

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Citations

Aug 2, 2012·Neural Plasticity·Rinske VlamingsYasin Temel
May 24, 2011·PloS One·Susanna PietropaoloYoon H Cho
Jul 21, 2016·Journal of Neurology·M JacobsUNKNOWN REGISTRY investigators of the European Huntington’s Disease Network
Aug 27, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Joseph Jankovic, Raymund A C Roos
Oct 24, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Jeffery D LongUNKNOWN Researchers of the PREDICT-HD Huntington's Study Group
Jun 15, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Tiago A MestreUNKNOWN Members of the MDS Committee on Rating Scales Development
Jan 11, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Parunyou JulayanontNikolaus R McFarland
Mar 16, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Ellen P HartUNKNOWN REGISTRY Investigators of the European Huntington's Disease Network
Feb 27, 2018·Journal of Huntington's Disease·Susanna WatersNicholas Waters

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