Abstract
In this study, the hypolipidaemic effect of an aqueous extract of the bark of Helicteres isora was investigated in streptozotocin (STZ)-induced diabetic rats. Administration of the bark extract of Helicteres isora (100 and 200 mg/kgb.w.) for 21 days resulted in significant reduction in serum and tissue cholesterol, phospholipids, free fatty acids and triglycerides in STZ diabetic rats. In addition to that, significant (p<0.05) decrease in high-density lipoprotein (HDL) whereas significant increase (p<0.05) low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) were observed in STZ diabetic rats, which were normalized after 21 days of bark extract treatment. The bark extract at a dose of 200 mg/kgb.w. showed much significant hypolipidaemic effect than at the dose of 100 mg/kgb.w.
References
Sep 1, 1991·The Journal of Pediatrics·H L GreeneH R Knapp
Apr 1, 1991·Diabetes·J W Baynes
Jul 1, 1989·Archives of Environmental Contamination and Toxicology·D L PhillipsL L Needham
Nov 17, 1989·JAMA : the Journal of the American Medical Association·D M HuseG A Colditz
May 1, 1989·Diabetologia·A FontbonneG E Rosselin
Dec 1, 1986·Metabolism: Clinical and Experimental·C E SparksJ M Amatruda
Apr 1, 1985·Pediatric Research·P Alaupovic, J Fernandes
Feb 1, 1974·Pediatric Research·P P ForgetP H Begemann
Jun 28, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·K FalholtW Falholt
May 1, 1968·Biochimica Et Biophysica Acta·K C RichardsM G Herrera
Jul 1, 1982·The Journal of Clinical Investigation·P N DurringtonD Steinberg
Mar 1, 1982·Diabetes·A H KissebahP W Adams
Nov 1, 1995·The American Journal of Clinical Nutrition·B Blades, A Garg
Jun 1, 1993·Diabetes·G F LewisG Steiner
Jun 1, 1993·The American Journal of Clinical Nutrition·E LevyE Seidman
Jun 1, 1993·Circulation·B G BrownJ J Albers
Jan 5, 2000·Journal of Ethnopharmacology·B K RaoC Appa Rao
Feb 17, 2001·Phytotherapy Research : PTR·N Pohocha, N D Grampurohit
Apr 13, 1963·Lancet·P J RANDLEE A NEWSHOLME
Mar 12, 2004·Journal of Ethnopharmacology·M MaghraniM Eddouks
Apr 6, 2005·Life Sciences·Benny Kwong Huat TanPeter Natesan Pushparaj
Jul 15, 2006·Journal of Ethnopharmacology·G KumarM Rajasekara Pandian
Citations
Feb 19, 2013·Current Microbiology·I V S Nimal ChristhudasP Agastian
Jan 16, 2014·Journal of Food Science and Technology·Nataraj LoganayakiSellamuthu Manian
Jan 26, 2013·Journal of Medicinal Food·Aysegul BayramogluHakan Senturk
Apr 13, 2013·Cytotechnology·Gokhan BayramogluDurdane Kolankaya
Apr 18, 2014·Applied Biochemistry and Biotechnology·M Priya RaniK P Padmakumari
Sep 29, 2009·Journal of Ethnopharmacology·Shefalee K BhavsarFlorian Lang
Jun 10, 2009·Journal of Ethnopharmacology·Shefalee K BhavsarDev D Santani
Feb 16, 2013·Food Chemistry·I V S Nimal ChristhudasP Agastian
Sep 18, 2013·Journal of Ethnopharmacology·Randhir SinghGirish Kumar Gupta
Sep 4, 2014·Asian Pacific Journal of Tropical Biomedicine·Nirmal Kumar, Anil Kumar Singh
Feb 7, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Christudas SunilSavarimuthu Ignacimuthu
Dec 15, 2019·Antibiotics·Suresh Mickymaray
Jan 30, 2020·Antibiotics·Mohammed Saleh Al Aboody, Suresh Mickymaray
Nov 8, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kumar Ganesan, Baojun Xu
Jul 31, 2020·Antibiotics·Suresh MickymarayAnand Paramasivam
Jul 11, 2012·The Journal of Pharmacy and Pharmacology·Douja Taleb-SenouciMalika Bouchenak