Hypolipidaemic and antioxidative effects of oligonol, a low-molecular-weight polyphenol derived from lychee fruit, on renal damage in type 2 diabetic mice

The British Journal of Nutrition
Jeong Sook NohTakako Yokozawa

Abstract

Oligonol was orally administered at 10 or 20 mg/kg body weight per d for 8 weeks to db/db mice with type 2 diabetes, and its effects were compared with those of the vehicle in db/db and m/m (misty, non-diabetic) mice. Serum and renal biochemical factors, protein expressions related to lipid metabolism and inflammation, and advanced glycation endproducts were measured. There were significant reductions in the serum lipid concentration, reactive oxygen species (ROS) and lipid peroxidation, as well as improvements in renal function parameters. In addition, oligonol treatment significantly decreased ROS levels and lipid peroxidation in the kidney. In particular, the renal lipid contents such as TAG and total cholesterol were significantly reduced in the oligonol-administered groups through the up-regulation of PPARα and down-regulation of sterol regulatory element-binding protein-1 in db/db mice. Moreover, oligonol inhibited non-fluorescent AGE formation and their receptor expression, suggesting that it could effectively inhibit AGE development caused by oxidative stress and/or dyslipidaemia in the kidney of db/db mice. Furthermore, augmented expressions of NF-κBp65, cyclo-oxygenase-2 and inducible NO synthase were down-regulated t...Continue Reading

References

May 1, 1978·Analytical Biochemistry·M Mihara, M Uchiyama
Jan 1, 1991·The American Journal of Clinical Nutrition·E NikiK Sato
Aug 1, 1963·Chemical & Pharmaceutical Bulletin·T MomoseK Ohashi
Aug 16, 1996·The Journal of Biological Chemistry·J Bubeck WardenburgP R Findell
Apr 21, 2001·Journal of Agricultural and Food Chemistry·P Sarni-ManchadoV Cheynier
Dec 1, 1964·Analytical Biochemistry·R F ITZHAKI, D M GILL
Jul 24, 2004·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Peter Celec
Dec 29, 2004·Diabetes Research and Clinical Practice·Nessar Ahmed
May 5, 2006·Kidney International·C W ParkY Guan
Jun 8, 2007·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Eun-Hye JoKyung-Sun Kang
Jan 10, 2008·The Journal of Clinical Endocrinology and Metabolism·Su-Yen Goh, Mark E Cooper
Jan 29, 2008·Photochemistry and Photobiology·Joydeb Kumar KunduYoung-Joon Surh
Jul 5, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Anna Csiszar, Zoltan Ungvari
Oct 14, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hajime FujiiAshley Roberts
Nov 15, 2008·Molecular Medicine·Katja RabeUli C Broedl

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Citations

Jan 27, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·C HuY Dai
Jan 23, 2016·Oxidative Medicine and Cellular Longevity·Jeonghyeon BakJeon-Ok Moon
Jun 14, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Sung Hee KimJin-Taek Hwang
May 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Cicero L T ChangWen-Chin Yang
May 2, 2012·Asian Pacific Journal of Tropical Medicine·Mi-Ja Kim, Hye Kyung Kim
Apr 11, 2015·Nutrition Research and Practice·Jae Hyun AhnEun Ju Cho
Dec 19, 2020·Comprehensive Reviews in Food Science and Food Safety·Lei ZhaoZhuoyan Hu
Feb 20, 2015·Journal of Agricultural and Food Chemistry·Yu-Chi LinChang-Hung Chou
Nov 19, 2021·Critical Reviews in Food Science and Nutrition·Yao ChenZhiyong He

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