PMID: 3761173Jul 1, 1986Paper

Hypolipidemic activity of N,N-dimethyl-n-octadecylamine borane in rodents

Journal of Pharmaceutical Sciences
I H HallG Futch

Abstract

N,N-Dimethyl-n-octadecylamine borane proved to be an effective hypolipidemic agent in rodents, lowering both serum cholesterol and triglyceride levels by greater than 40% after 16 d of administration. The agent lowered serum lipid levels by inhibiting the enzymatic activity of rate-limiting enzymes of both de novo cholesterol and triglyceride pathways in the liver. The reduction led to lower levels of lipids in the liver and small intestine tissues, with a reduction of the cholesterol and triglyceride levels of the serum low density lipoprotein (LDL) fraction. Concurrently, the cholesterol level of high density lipoproteins (HDL) was significantly elevated in rats after 14 d of treatment. The drug caused an increased rate of cholesterol clearance from the body, essentially via the feces. The ability of the agent to modulate the cholesterol levels of LDL and HDL fractions suggests that the agent should be an effective agent for the treatment of hyperlipidemic states in humans.

References

Oct 1, 1978·European Journal of Biochemistry·S BalasubramaniamS Venkatesan
Mar 1, 1981·Journal of Pharmaceutical Sciences·I H HallB F Spielvogel
Aug 29, 1981·Lancet·T A MiettinenT Kumlin
Aug 1, 1983·Journal of Pharmaceutical Sciences·I H HallG H Cocolas
Feb 1, 1982·The Journal of Clinical Investigation·A ChaitJ D Brunzell
Sep 1, 1955·The Journal of Clinical Investigation·R J HAVELJ H BRAGDON
Sep 1, 1964·Clinica Chimica Acta; International Journal of Clinical Chemistry·A T NESSA C PEACOCK
Jul 1, 1935·The Biochemical Journal·C P Stewart, E B Hendry

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Citations

Jan 1, 1991·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·I H HallB F Spielvogel
Apr 1, 1992·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·I H HallK W Morse
Sep 1, 1991·Archiv der Pharmazie·I H HallE L Docks

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