Abstract
We have previously reported the lipid-lowering effects of a Korean rice cookie called dasik (RCD) in comparison with a western style cookie. In this study, Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine) fruit-supplemented RCD (SRCD) was added to a diet, and the hypolipidemic and antidiabetic effects of different diets were examined by using the ICR and db/db mouse models, respectively. ICR mice were fed the AIN-76 diet, or high-fat diet (HFD), or the RCD- or SRCD-supplemented HFD (10%, w/w) for 9 weeks (n = 7 per group). Compared with the RCD group, plasma and hepatic triglyceride and cholesterol concentrations were decreased in the SRCD group. Hepatic expressions for fatty acid and cholesterol synthesis were downregulated, whereas those for beta-oxidation and cholesterol export were upregulated (P < .05). The antidiabetic effects of SRCD were tested in db/db mice for 10 weeks (n = 7 per group). Glucose tolerance was improved in the SRCD group through the regulation of gluconeogenic enzymes and biomarkers related to the insulin signaling pathway (P < .05). In addition, SRCD increased the expression levels of antioxidative enzymes, and decreased those of inflammatory cytokines (P < .05). Moreover, oxidative stress,...Continue Reading
References
Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Feb 1, 1994·Free Radical Biology & Medicine·N W KooyJ S Beckman
Dec 14, 2001·Nature·M Brownlee
Dec 16, 2004·The Journal of Clinical Investigation·Shigetada FurukawaIichiro Shimomura
Apr 13, 2007·Physiological Reviews·David B SavageGerald I Shulman
Jul 16, 2008·European Journal of Pharmacology·Lian Yu GuoYeong Shik Kim
Mar 28, 2009·Journal of Food Science·S-H KimS-H Yoo
Sep 23, 2009·The Journal of Endocrinology·Yi Lin, Zhongjie Sun
Feb 2, 2010·Journal of Physiology and Biochemistry·M Sabater-MolinaS Zamora
Mar 29, 2011·Journal of Ethnopharmacology·Dae Young KwonSunmin Park
Jun 8, 2011·Immunology Letters·Sun Young ParkSang-Joon Lee
Jun 16, 2011·BioFactors·Yuko NakamuraJinichiro Koga
Feb 22, 2012·Journal of Physiology and Biochemistry·Isabel Bondia-PonsJ Alfredo Martinez
Jul 17, 2012·Journal of Lipid Research·Rai Ajit K SrivastavaRoger S Newton
Mar 28, 2013·Current Medicinal Chemistry·H ManggeD Fuchs
Jun 25, 2013·Molecular and Cellular Endocrinology·Xin WangChunxu Hai
Feb 1, 2014·Nutrients·Héctor Merino-AguilarFrancisco Javier Alarcón-Aguilar
Mar 19, 2014·The Journal of Nutritional Biochemistry·Chongming WuXudong Xu
Sep 24, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andrei MocanIoan Tilea
Apr 19, 2015·Journal of Translational Medicine·Bhesh Raj SharmaDong Young Rhyu
Dec 3, 2016·Nutrition Research and Practice·Sun Hee HongYeong Ok Song
Jan 17, 2017·The Journal of Nutritional Biochemistry·Hyo Jin ParkUn Ju Jung
Apr 21, 2017·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·Agnieszka SzopaHalina Ekiert