Hypolipidemic effect and activation of Lecithin Cholesterol Acyl Transferase (LCAT) by aqueous extract of Spirulina platensis during toxicological investigation

BMC Nutrition
Vicky Jocelyne Ama MoorJeanne Yonkeu Ngogang

Abstract

Spirulina platensis produced in Nomayos (Cameroon) is used as a dietary supplement. S. platensis is known as a neutraceutical with many beneficial effects on humans like lipid-lowering action. This study aims to investigate the mechanism of hypolipidemic action of aqueous extract of Spirulina platensis (S. platensis) through the toxicological studies. In this study, we included two month old Wistar rats, weighing between 180 and 200 g. Aqueous S. platensis was extracted and prepared using standard methods. The rats received a supplementation of S. platensis at 5000 mg/Kg of body weight as single dose in acute toxicity whereas different doses (250, 500, 1000 mg / kg body weight) were administered in subacute toxicity compared to control. Acute and subacute toxicities were determined according to the guidelines 420 (14 days) and 407 (28 days) of the Organization for Economic Cooperation and Development (OECD) respectively. Biochemical parameters such as urea, creatinine, total and direct bilirubin, lipid profile and transaminases; and histopathological analysis of the liver and kidneys were used to evaluate the toxicity of S. platensis on these Wistar rats. Plasmatic hydroxymethyl glutaryl coenzyme A reductase (HMG CoA reductase)...Continue Reading

References

Jan 1, 1997·Sub-cellular Biochemistry·P S ColemanL Sepp-Lorenzino
Aug 26, 1998·Biochemical and Biophysical Research Communications·B B VadirajaK M Madyastha
Oct 8, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·M Dobiásová, J J Frohlich
Mar 21, 2001·The American Journal of Cardiology·A M Gotto
Jul 11, 2001·Biochemical and Biophysical Research Communications·V B Bhat, K M Madyastha
Mar 24, 2004·Journal of Ethnopharmacology·Jaouad El HilalyBadiâa Lyoussi
Aug 6, 2004·Chemico-biological Interactions·Shukkur Muhammed FarooqPalaninathan Varalakshmi
Jun 10, 2005·Microbiology and Molecular Biology Reviews : MMBR·Jan Sapp
Apr 9, 2008·Ecotoxicology and Environmental Safety·Ali KaradenizNejdet Simsek
Aug 12, 2008·Phytotherapy Research : PTR·Ali KaradenizFikret Celebi
Jun 13, 2009·International Journal of Biological Sciences·Mohamed F IsmailAllal Ouhtit
Jul 17, 2010·Cardiovascular Therapeutics·Ruitang Deng, Te-Jin Chow
Oct 23, 2012·Molecular Biology of the Cell·Yien Che TsaiAllan M Weissman
Jan 10, 2014·Toxicology International·Enegide ChineduFidelis Solomon Ameh
Jan 1, 2013·Journal of Traditional and Complementary Medicine·Ming-Jyh SheuChieh-Hsi Wu

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