Hypolipidemic effects of fucoidan fractions from Saccharina sculpera (Laminariales, Phaeophyceae)

International Journal of Biological Macromolecules
Dandan RenLong Wu

Abstract

Fucoidan is a kind of brown algae-derived macromolecule suggested to have hypolipidemic activity. Saccharina sculpera has attracted interest because it is rich in fucoidan. The monosaccharide composition and structural characteristics of isolated fractions (F1, F2 and F3) were determined using high-performance liquid chromatography (HPLC), Fourier transform infrared spectroscopy (FTIR) and nuclear magnetic resonance spectroscopy (NMR). The hypolipidemic effects of fucoidan fractions from Saccharina sculpera cultured in northern China were clarified by measuring cholesterol levels, antioxidative indicators and hepatic gene mRNA expression using an established hyperlipidemic Wistar rat model. The results showed that F1 is an acetylated galactofucan and that F2 consists of fucose, galactose, mannose and glucuronic acid. F3 is an acetylated galactofucan with high fucose. Fucoidan fractions from Saccharina sculpera could effectively reduce the level of lipids in serum by reducing the TG, TC, and LDL-C levels and increasing HDL-C levels and could effectively prevent lipid accumulation in the liver. The findings obtained from hepatic gene expression showed that fucoidan could inhibit cholesterol synthesis via downregulation of HMG-CoA...Continue Reading

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Citations

Apr 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tatiana A KorolenkoVaclav Vetvicka
Nov 6, 2020·The American Journal of Chinese Medicine·Jingjing LiJianye Wu
Feb 14, 2021·International Journal of Pharmaceutics·Phuong H L TranThao T D Tran
Dec 10, 2020·International Journal of Molecular Sciences·Philipp Dörschmann, Alexa Klettner
Jun 16, 2021·Carbohydrate Polymers·Jiarui ZhaoShuliang Song

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