Hyponatraemia and its prognosis in acute heart failure is related to right ventricular dysfunction

Heart
Heesun LeeByung-Hee Oh

Abstract

Hyponatraemia is a well-known predictor of clinical outcomes in heart failure (HF). However, the mechanism remains poorly understood. Previous reports suggest that hyponatraemia is related to right HF. We sought to evaluate the association between right ventricular (RV) dysfunction and hyponatraemia, and the impact of this relationship on the prognosis of patients with acute heart failure (AHF). This is a nested case-control study of the Korean Acute Heart Failure registry. Among 2935 AHF patients enrolled prospectively and consecutively at four tertiary hospitals in Korea from 2011 to 2014, 116 patients with severe persistent hyponatraemia, defined as serum sodium level <130 mmol/L at admission and <135 mmol/L before discharge, were matched with 232 controls, based on propensity scores for hyponatraemia. RV function was assessed with fractional area change (FAC) by echocardiography. RV dysfunction (FAC <35%) was more prevalent in patients with severe persistent hyponatraemia than in those without (81.0% vs 33.6%, p<0.001). Hyponatraemia was strongly associated with RV dysfunction (adjusted OR 8.00, 95% CI 4.50 to 14.22, p<0.001), but not with left ventricular dysfunction (adjusted OR 1.21, 95% CI 0.74 to 1.50, p=0.308). RV dys...Continue Reading

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References

Apr 1, 1995·Journal of the American College of Cardiology·T G Di SalvoG W Dec
Sep 17, 2002·Heart·R A Bleasdale, M P Frenneaux
Nov 26, 2002·Journal of the American College of Cardiology·Mark T KearneyJames Nolan
Jan 3, 2006·Journal of the American College of Cardiology·Robert W Schrier
Apr 12, 2006·Archives of Internal Medicine·Alexander GoldbergDoron Aronson
Mar 27, 2007·JAMA : the Journal of the American Medical Association·Marvin A KonstamUNKNOWN Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study With Tolvaptan (EVEREST) Investigators
Apr 28, 2007·European Journal of Heart Failure·Jesper KjaergaardChristian Hassager
Oct 10, 2007·Archives of Internal Medicine·Mihai GheorghiadeChristopher M O'Connor
Mar 22, 2008·American Journal of Respiratory and Critical Care Medicine·Paul R ForfiaPaul M Hassoun
Sep 2, 2008·Heart Failure Reviews·Dimitrios FarmakisMihai Gheorghiade
Apr 3, 2009·Statistics in Medicine·Arvid Sjölander
Sep 15, 2010·Heart Failure Reviews·Luca BettariChristopher M O'Connor
Jan 15, 2013·The American Journal of Cardiology·Naoki SatoUNKNOWN ATTEND Investigators
Jun 5, 2013·European Heart Journal Cardiovascular Imaging·Patrizio LancellottiUNKNOWN Scientific Document Committee of the European Association of Cardiovascular Imaging
Mar 5, 2014·Circulation·Mark K Friedberg, Andrew N Redington
Sep 18, 2014·Internal Medicine Journal·S BloomJ Lubel
Jan 7, 2015·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Roberto M LangJens-Uwe Voigt

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Citations

Sep 29, 2018·Heart·Gregorio Paolo MilaniSebastiano Ag Lava

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