Hyponatremia in patients with esophageal cancer treated with chemotherapy including cisplatin

Esophagus : Official Journal of the Japan Esophageal Society
Ayako ShimadaYuko Kitagawa

Abstract

Little is known about hyponatremia in patients with esophageal cancer treated with cisplatin-based chemotherapy. The aim of this study was to analyze the risk factors for hyponatremia and its effect on outcomes in patients with esophageal cancer treated with chemotherapy including cisplatin. We retrospectively analyzed the records of 137 patients with esophageal cancer who received chemotherapy including cisplatin for the first time between January 2011 and December 2014. Hyponatremia (Na < 135 mEq/L) was seen in 77 patients (59%), of whom 29 had Grade 3 (120 ≤ Na < 130 mEq/L) or Grade 4 (Na < 120 mEq/L) hyponatremia. We divided patients into the hyponatremia group (patients with Na < 130 mEq/L) and the control group (patients with Na ≥ 130 mEq/L), and compared the results between the two groups. Three patients (2%) were diagnosed with the syndrome of inappropriate secretion of antidiuretic hormone. The serum sodium level before starting chemotherapy was significantly lower and white blood cell count was significantly higher in the hyponatremia group. Appetite loss was seen significantly more often in the hyponatremia group as the chemotherapy-related adverse effect. There was no significant difference in overall survival betwe...Continue Reading

References

Feb 1, 1985·Annals of Internal Medicine·R J AndersonR W Schrier
Jan 1, 1984·Medical and Pediatric Oncology·J KurtzbergT R Kinney
Dec 31, 1998·The New England Journal of Medicine·D P KelsenJ A Roth
Jun 7, 2002·Lancet·UNKNOWN Medical Research Council Oesophageal Cancer Working Group
Aug 2, 2002·American Journal of Clinical Oncology·Lequn CaoDavid Sumoza
Dec 12, 2003·Clinical Lung Cancer·Akila V IyerAnthony S Arcenas
Jul 11, 2006·The New England Journal of Medicine·David Cunningham MAGIC Trial Participants
Aug 19, 2007·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Harry Raftopoulos
Feb 15, 2008·Kidney International·N Pabla, Z Dong
Apr 7, 2009·Gynecologic Oncology·J B Trimbos
Jul 14, 2010·Southern Medical Journal·Tamim HamdiAshok Patel
Jun 17, 2011·Nephron. Clinical Practice·Pasquale EspositoAntonio Dal Canton
May 24, 2012·The Oncologist·Jorge J CastilloEric Justice
Jul 22, 2014·Cancer Science·Shuichi HironakaUNKNOWN Japan Esophageal Oncology Group/Japan Clinical Oncology Group
Jan 27, 2015·Esophagus : Official Journal of the Japan Esophageal Society·Hiroyuki KuwanoAkio Yanagisawa
Feb 18, 2016·Journal of Cancer Research and Therapeutics·Erman AtasGokhan Kalkan

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Citations

Jun 9, 2020·Frontiers in Oncology·Ignazio VerziccoAderville Cabassi

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