Hyponatremia induced by oxcarbazepine in children

Epilepsy Research
P BorusiakH E Boenigk

Abstract

We report the case of a 12-year-old girl with severe clinically relevant hyponatremia (118 mmol/l) and hypochloremia (81 mmol/l) during treatment with oxcarbazepine (OCBZ). The adverse effects were rapidly reversible after discontinuation of OCBZ and did not occur when exposed to carbamazepine. We reviewed the charts of 48 patients who received OCBZ as in-patients in our epilepsy centre and found hyponatremia in nine and hypochloremia in four. The mean sodium level of all patients was 139 mmol/l (range 118-150 mmol/l). We did not see any correlation between sodium or chloride levels and dose of OCBZ or blood serum level of the active metabolite 10-OH-carbazepine. We emphasize that children are at risk of developing electrolyte disturbances during treatment with OCBZ and thus the level of at least sodium should be monitored in those patients.

References

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Citations

Mar 3, 2010·CNS Drugs·Dean P Sarco, Blaise F D Bourgeois
Apr 26, 2006·Southern Medical Journal·Zachary Tebb, Joseph D Tobias
Apr 22, 2006·Therapeutic Drug Monitoring·Mario FurlanutMaurizio Pecorari
Aug 26, 2004·British Journal of Clinical Pharmacology·J M van OpstalF De Heer
Mar 9, 2010·Thérapie·Régis BouquiéUNKNOWN le groupe Suivi Thérapeutique Pharmacologique de la Société Française de Pharmacologie et de Thérapeutique
Oct 16, 2016·Expert Opinion on Drug Safety·Xi Lu, Xuefeng Wang
Oct 21, 2003·The Annals of Pharmacotherapy·Biff F PalmerMalcolm Lader
Nov 5, 2003·Arquivos de neuro-psiquiatria·Maurus Marques de Almeida HolandaJosé Alberto Gonçalves da Silva
Nov 10, 2020·The Journal of Applied Laboratory Medicine·Grace M KronerKamisha L Johnson-Davis
Dec 19, 2020·Seizure : the Journal of the British Epilepsy Association·Ahmad BeydounLieven Lagae

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