Hyponatremia is associated with higher NT-proBNP than normonatremia after prolonged exercise

Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine
Gregory HarrisPaul McCrory

Abstract

To determine the incidence of and risk factors for exercise-associated hyponatremia (EAH) in cyclists completing a long-distance bike ride and to assess whether postexercise serum NT-proBNP concentration (brain natriuretic protein precursor) differed between riders with and without EAH. Observational study. "Around the Bay in a Day" cycle event, October 2010. One hundred thirty-nine cyclists prospectively enrolled, with 90 completing 210 or 250 km. Body weight change and fluid intake during the event, and postevent serum sodium concentration ([Na+]) and NT-proBNP concentration ([NT-proBNP]). Four riders (4.5%) were hyponatremic ([Na+] < 135 mmol/L). The lowest postride [Na+] was 126 mmol/L. Hyponatremia was associated with a mean weight gain of 3.4 kg (3.9% of total body weight). Significant negative correlations were found between postride [Na+] and change in weight (r = -0.34; P < 0.01) and fluid intake when expressed as total volume (r = -0.35; P < 0.01), mL/kg body weight (r = 0.33; P < 0.01), mL·kg·h (r = -0.27; P < 0.01), or mL/h (r = -0.29; P < 0.01). NT-proBNP concentrations levels in 3 of the 4 hyponatremic subjects were markedly elevated compared with eunatremic subjects matched for age, sex, distance ridden, training...Continue Reading

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Citations

Dec 17, 2014·Wilderness & Environmental Medicine·Brad L BennettMitchell H Rosner
Jan 1, 2014·Journal of Clinical Medicine·Caterina UrsoGregorio Caimi
May 28, 2014·Wilderness & Environmental Medicine·Martin D HoffmanMartin Schwellnus
Mar 8, 2016·Wilderness & Environmental Medicine·Martin D HoffmanMitchell H Rosner
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Mar 5, 2015·Wilderness & Environmental Medicine·Emily A PearceMartin D Hoffman
Nov 3, 2016·The Physician and Sportsmedicine·Martin D HoffmanR Tyler Hamilton
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Jan 1, 2015·Medicine and Science in Sports and Exercise·Martin D Hoffman, Kristin J Stuempfle
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Jun 24, 2015·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Tamara Hew-ButlerJoseph G Verbalis
Jan 3, 2019·Sports Medicine and Arthroscopy Review·Martin D Hoffman
Nov 9, 2012·Medicine and Science in Sports and Exercise·Martin D HoffmanKristin J Stuempfle

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