Hypophagic and dipsogenic effects of central 5-HT injections in pigeons

Brain Research Bulletin
S M SteffensJosé Marino-Neto

Abstract

The present work describes a series of experiments designed to examine the possible role of central 5-HT circuits in the control of feeding and drinking in pigeons. Acute effects (within 1 h) of intracerebroventricular (ICV) injections of 5-HT (0, 9.7, 19.4, 38.7, 77.5, 155, and 310 nmol) in 24-h food-deprived (24FD) pigeons included strong hypophagic and dipsogenic responses at the three higher doses. Total food intake and the duration of feeding behavior were reduced, and latency for the start of eating increased. Total 1-h water intake in 5-HT-treated pigeons usually increases to reach a volume equivalent to 10% of their body weight. Similarly, potent dipsogenic effects of ICV 5-HT, but no food intake decreases, were observed in food-satiated animals. Feeding behavior induced by ICV injection of adrenaline (30 nmol) in satiated pigeons was abolished by previous (20 min before) ICV 5-HT (155 nmol) injections. Catecholamine treatment did not affected the dipsogenic effect of 5-HT injections. Decreases in food intake were similarly observed after ICV or subcutaneous injections of equimolar 5-HT doses (155 nmol) in 24FD pigeons, but systemic 5-HT injections evoked no drinking behavior. Central injections of the 5-HT(2a/2c) agoni...Continue Reading

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Citations

Oct 16, 2012·Veterinary Research Communications·Morteza ZendehdelRohollah Montazeri
Jun 28, 2012·The Journal of Physiological Sciences : JPS·Morteza ZendehdelElham Amini
Apr 26, 2013·The Journal of Physiological Sciences : JPS·Morteza ZendehdelShahin Hassanpour
Mar 19, 2002·Physiology & Behavior·A Saadoun, M C Cabrera
Mar 30, 2002·Brain Research Bulletin·Martin MetzgerKatharina Braun
Dec 25, 2013·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Jorge J Pérez MaceiraManuel Aldegunde
Feb 1, 2008·Regulatory Peptides·Eduardo Simão da SilvaJosé Marino-Neto
Aug 12, 2010·Behavioural Brain Research·S TejadaS Esteban
Jun 30, 2009·Journal of Chemical Neuroanatomy·Cristiane MeneghelliJosé Marino-Neto
May 12, 2009·Behavioural Brain Research·Murilo Marcos Dos SantosJosé Marino-Neto
Nov 18, 2008·Journal of Animal Physiology and Animal Nutrition·A Saadoun, M C Cabrera
Sep 25, 2012·Journal of Veterinary Science·Morteza ZendehdelRamin Mazaheri Nezhad Fard
Mar 15, 2006·Brazilian Journal of Biology = Revista Brasleira De Biologia·P L Cedraz-MercezL C Reis

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