PMID: 686330Jul 1, 1978

Hypophosphataemia and its consequences in patients following open heart surgery

R SwaminathanG L Hill


Plasma phosphate concentration (Pi), red cell 2,3-diphosphoglycerate (2,3-DPG) and adenosine triphosphate (ATP) concentrations were measured pre-operatively and at intervals after operation for 30 h in twelve patients (nine males and three females, 44--61 years of age), who underwent open heart surgery. All patients received intravenous injections of glucose, insulin and potassium at regular intervals. In all patients studied Pi decreased within hours following operation, remained low for about 6 h and pre-operative values were reached by 18 h. Pi decreased from 1.04 +/- 0.6 mmol/litre (mean +/- s.e. mean) to 0.32 +/- 0.06 mmol/litre. This fall in Pi was accompanied by a small but significant fall in 2,3-DPG (from 14.8 +/- 0.60 mumol/g Hb to 11.2 +/- 0.60 mumol/g Hb). ATP concentration did not change significantly. The calculated P50 (partial pressure of oxygen at which there was 50% saturation of haemoglobin) decreased by 1.2 mmHg. The regular fall in Pi which is probably due to the glucose-insulin-potassium injections was of short duration and had very little effect on red cell 2,3-DPG and ATP.


Dec 25, 1976·Lancet·R SwaminathanD B Morgan
Jun 1, 1975·The Surgical Clinics of North America·R McConn
Jun 1, 1976·The Journal of Surgical Research·G L HillS J Dudrick
May 12, 1977·The New England Journal of Medicine·J H NewmanP Ziporin
Jun 20, 1974·The New England Journal of Medicine·P R CraddockH S Jacob
Sep 1, 1972·Annals of Surgery·S J DudrickA T Maynard
Jan 29, 1972·British Medical Journal·M G Betro, R W Pain
Dec 23, 1971·The New England Journal of Medicine·H S Jacob, T Amsden
Nov 1, 1969·The American Journal of Cardiology·D Sodi-PallaresJ Ponce de León
Mar 1, 1971·The Journal of Clinical Investigation·A J BellinghamC Lenfant


May 30, 2001·Nutrition·T Schricker, R Lattermann
Apr 1, 1980·Anaesthesia·M A Thompson, M P Broadbent
Oct 1, 2005·The American Journal of Medicine·André Gaasbeek, A Edo Meinders
Sep 1, 1996·Annals of Clinical Biochemistry·M Crook, R Swaminathan

Related Concepts

Adenosine Triphosphate, Chromium Ammonium Salt
Diphosphoglyceric Acids
Glucose, (beta-D)-Isomer
Heart Valves
Postoperative Complications

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