Hypophosphatemia after nontraumatic intracranial hemorrhage

Acta Anaesthesiologica Scandinavica
E JunttilaT Ala-Kokko

Abstract

The aim of this study was to assess the incidence and contributing factors of hypophosphatemia and the association with poor long-term outcome after nontraumatic intracranial hemorrhage. This was a prospective, observational study of patients with nontraumatic intracranial hemorrhage (i.e., aneurysmal or perimesencephalic subarachnoid hemorrhage, or spontaneous intracerebral or intraventricular hemorrhage) treated in the intensive care unit (ICU) at our university hospital. Plasma phosphate concentrations were measured serially in 2-day sections during the 6 day study period. The ICU mortality was recorded, 3-month and 1-year outcomes were assessed using the Glasgow Outcome Scale. One hundred patients were enrolled. The frequency of hypophosphatemia (Pi ≤ 0.65 mmol/l) was 70%. Chronic hypertension, acute hydrocephalus, and diffuse brain edema were more common in patients with hypophosphatemia compared with normophosphatemics (44% vs. 21%, P = 0.021; 59% vs. 33%, P = 0.021; and 43% vs. 13%, P = 0.004, respectively). Hypophosphatemic patients had higher maximum SOFA scores [10 (7-11) vs. 7.5 (5.75-10), P = 0.024]. Initial phosphate concentration correlated inversely with APACHE II score on admission (ρ = -0.304, P = 0.002) and SO...Continue Reading

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Citations

Aug 14, 2020·Journal of Intensive Care Medicine·Jeremy Cheuk Kin SinAlexis Tabah
Dec 4, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Annika Reintam BlaserMette M Berger
Aug 13, 2021·Acta Anaesthesiologica Scandinavica·Mai Erritzøe-JervildKirsten Møller

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