PMID: 9004174Nov 1, 1996Paper

Hypophosphatemia induced in mice by transplantation of a tumor-derived cell line from a patient with oncogenic rickets

Journal of Pediatric Endocrinology & Metabolism : JPEM
S A ChalewC C Sun

Abstract

A cultured cell line was derived from a hemangiopericytoma obtained at surgery from a 9 year-old boy with hypophosphatemic rickets. Hypophosphatemia and metabolic bone disease were cured in the patient after tumor removal. Cells from passage 5 were transplanted into 8 week-old athymic female mice. Additional animals received innocula of cells thawed from the stored original tumor tissue, as well as MRC-5 fibroblasts. Serum phosphate levels 3-7 months post-transplantation were lowest in mice which received the cultured cell line (n = 5) 6.1 +/- 0.6 mg/dl (p < 0.05 compared to the other groups), thawed tumor cells (n = 8) 7.2 +/- 0.7 mg/dl, MRC fibroblasts (n = 4) 8.1 +/- 1.0 mg/dl, no transplant (n = 10) 8.7 +/- 1.9 mg/dl. Repeat of the experiment with cultured tumor cells from passage 12 no longer altered phosphate levels. A substance produced and release by the tumor in situ and by tumor-derived cultured cells is capable of producing hypophosphatemia. Experimental manipulation of functional tumor-derived cell lines may help elucidate the factor(s) causing hypophosphatemia in oncogenic osteomalacia/rickets.

References

Jul 1, 1989·The American Journal of Surgical Pathology·M A NuovoS A Chalew
Jul 1, 1989·Clinical Pediatrics·A HanukogluR W Bright
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Sep 1, 1984·The American Journal of Medicine·E A Ryan, E Reiss

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Citations

Aug 12, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jyothsna Gattineni, Michel Baum
Oct 18, 2000·Endocrinology and Metabolism Clinics of North America·L A DiMeglioM J Econs
Feb 24, 2010·Nature Reviews. Nephrology·Emily G Farrow, Kenneth E White
Aug 22, 2000·Archives of Disease in Childhood·P S Rowe
May 3, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Maria Goretti M G Penido, Uri S Alon
Jan 5, 2011·European Journal of Pediatrics·Uri S Alon
Jan 5, 2000·Kidney International·M K Drezner
Mar 14, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Harish K DattaR Dermot G Neely
May 3, 2005·Cytokine & Growth Factor Reviews·Xijie Yu, Kenneth E White
Apr 7, 2007·Clinical Nuclear Medicine·Michael C Roarke, Ba D Nguyen
Aug 5, 1998·Current Opinion in Nephrology and Hypertension·P S Rowe
Mar 17, 2010·Expert Review of Endocrinology & Metabolism·Emily G Farrow, Kenneth E White

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