Hypophyseal Involvement in Immunoglobulin G4-Related Disease: A Retrospective Study from a Single Tertiary Center

International Journal of Endocrinology
Yang LiuHuijuan Zhu

Abstract

This study aims to outline the clinical features and outcomes of IgG4-related hypophysitis (IgG4-RH) patients in a tertiary medical center. We reviewed clinical manifestations and imaging and pituitary function tests at baseline, as well as during follow-up. Ten patients were included. The mean age at diagnosis of IgG4-RH was 48.4 (16.0-64.0) years. An average of 3 (0-9) extrapituitary organs were involved. Five patients had panhypopituitarism, three had only posterior hypopituitarism, one had only anterior hypopituitarism, and one had a normal pituitary function. One patient in our study had pituitary mass biopsy, lacking IgG4-positive cells despite lymphocyte infiltration forming an inflammatory pseudotumor. Five patients with a clinical course of IgG4-RH less than nine months and a whole course of IgG4-RD less than two years were managed with glucocorticoids, while three patients with a longer history were administered glucocorticoids plus immunosuppressive agents. One patient went through surgical excision, and one patient was lost to follow-up. All patients showed a prompt response clinically, but only three patients had normalized serum IgG4 levels. Two patients who took medications for less than six months relapsed. Conc...Continue Reading

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Citations

Jan 5, 2019·Pituitary·Keitaro KanieYutaka Takahashi
Jan 14, 2020·International Journal of Endocrinology·Yujuan LiFengao Li
Mar 7, 2021·Journal of Pediatric Endocrinology & Metabolism : JPEM·Ved Bhushan AryaCharles R Buchanan
Apr 11, 2021·Endocrine·Alireza AmirbaiglooMehdi Zeinalizadeh

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Methods Mentioned

BETA
biopsy
biopsies
hormone replacement therapy

Software Mentioned

GraphPad Prism
GraphPad

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