Hypophysectomy and hormonal therapy modulate mK1-immunoreactive duct cells in the mice sublingual glands.

Journal of Molecular Histology
Shingo KurabuchiK Hosoi

Abstract

The immunocytochemical localization of a true tissue kallikrein, mK1, in mouse sublingual glands (SLGs) was examined following hypophysectomy and hormonal replacement therapy. In the glands of intact mice (14 weeks of age), mK1 was detected in the striated ducts (SDs). Full-fledged granular cells were scattered in the SDs of male mice (but not in those of female mice), showing a cellular mosaic distribution of mK1 with some being positive and others being negative. mK1 was also detected in transitional-type granular cells, though the secretory granules were too small and scarce to be visible by a light microscopy. Hypophysectomy in male mice resulted in the atrophy and loss of secretory granules in many SD cells. Granulation recovered after the repeated injection of 5alpha-dihydrotestosterone (DHT), 3,5,3'-triiodo-L: thyronine (T3), and dexamethasone (Dex), given either alone or in combination to the hypophysectomized mice. The concomitant injection of DHT and T3, with or without Dex, resulted in the reappearance of the full-fledged granular cells, only some of which were mK1-positive. Electron microscopy revealed mK1 to be present exclusively in the secretory granules of these mK1-positive cells, and no ultrastructural differe...Continue Reading

References

Apr 1, 1987·The Histochemical Journal·D J Hazen-MartinJ A Simson
Oct 1, 1987·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J I MorrellT Barka
Sep 1, 1968·Biochemistry·A P SmithE M Shooter
Mar 31, 1983·Biochimica Et Biophysica Acta·K HosoiT Ueha
Jan 1, 1984·Cell and Tissue Research·S MatsuuraK Suzuki
Aug 1, 1980·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·T Barka
Apr 1, 1980·Journal of Neurochemistry·R W StachE M Shooter
Jan 1, 1993·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J D Penschow, J P Coghlan
May 25, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S KurabuchiE W Gresik
Jan 19, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Shingo KurabuchiEdward W Gresik
Oct 27, 2004·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Shingo KurabuchiKazuo Hosoi

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Citations

Jan 1, 2009·The Journal of Medical Investigation : JMI·Shingo KurabuchiKazuo Hosoi

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