PMID: 11920708Mar 29, 2002Paper

Hypophysiotropic neurons of the paraventricular nucleus respond in spatially, temporally, and phenotypically differentiated manners to acute vs. repeated restraint stress: rapid publication

The Journal of Comparative Neurology
Victor Viau, Paul E Sawchenko

Abstract

Hypothalamic-pituitary-adrenal (HPA) responses to stress are initiated by parvicellular neurosecretory neurons in the medial parvicellular (mp) part of the paraventricular hypothalamic nucleus (PVH), which express corticotropin-releasing factor (CRF), among other neuropeptides. We have used an approach guided by patterns of stress-induced Fos expression to explore the manner in which anatomically and phenotypically defined components of the mpPVH respond to acute vs. repeated restraint stress. Hormonal indices of HPA activation in animals exposed to the last of 14 daily repeated restraint sessions were significantly lower than those in rats receiving a single restraint episode. Although this habituation was paralleled by global decrements in activation patterns across all PVH compartments, clear spatial-temporal differences in recruitment profiles were noted between dorsal and ventral aspects of the mpPVH. Thus, acute restraint provoked a biphasic Fos induction, which occurred first within the mpPVH and in an adjoining population of somatostatinergic cells in the periventricular region and only later within other aspects of the PVH. By contrast, Fos responses of habituated animals were monophasic and focused decisively within a...Continue Reading

References

Aug 1, 1977·Journal of Comparative and Physiological Psychology·J W HennessyS Levine
Mar 1, 1976·Pharmacology, Biochemistry, and Behavior·K L Keim, E B Sigg
Jan 1, 1991·Progress in Brain Research·L W Swanson
Apr 8, 1990·The Journal of Comparative Neurology·S Pretel, D Piekut
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S CeccatelliT Hökfelt
May 1, 1972·The American Journal of Physiology·J W Mason
Jan 1, 1983·Annual Review of Neuroscience·L W Swanson, P E Sawchenko
Jan 1, 1994·Peptides·G A OlsonA J Kastin
Apr 1, 1993·Frontiers in Neuroendocrinology·F A Antoni
Jan 1, 1993·Annual Review of Pharmacology and Toxicology·R N Pechnick
Mar 1, 1993·Trends in Endocrinology and Metabolism : TEM·M F Dallman
Feb 1, 1991·Journal of Neuroendocrinology·P M Plotsky
Feb 1, 1946·The Anatomical Record·M ABERCROMBIE
Oct 1, 1992·Journal of Neuroendocrinology·M F DallmanC S Cascio

❮ Previous
Next ❯

Citations

Mar 29, 2008·Experimental Brain Research·Ilan A Kerman
Apr 27, 2013·Journal of Chemical Neuroanatomy·André V da SilvaJackson C Bittencourt
Feb 26, 2003·European Journal of Pharmacology·Gonzalo A Carrasco, Louis D Van de Kar
Dec 17, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Georg M SingewaldKarl Ebner
Mar 18, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Brenda BinghamVictor Viau
May 20, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Matthew N HillBoris B Gorzalka
Sep 6, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason J RadleySara A Romig-Martin
May 30, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason J RadleyPaul E Sawchenko
Jul 1, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason J Radley, Paul E Sawchenko
Jul 11, 2014·Journal of Chemical Neuroanatomy·Lu Xu
Dec 20, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Badowska-Szalewska EwaMoryś Janusz
Dec 15, 2011·General and Comparative Endocrinology·Lu XuTamás Kozicz
Apr 2, 2011·Physiology & Behavior·Jaidee K ZavalaKristin L Gosselink
Dec 1, 2009·Peptides·Andreas StengelYvette Taché
Sep 25, 2007·Brain, Behavior, and Immunity·Stephanie L BowersRandy J Nelson
Jul 14, 2007·Experimental Neurology·Mary F Dallman
May 23, 2007·General and Comparative Endocrinology·Tamás Kozicz
Apr 3, 2007·General and Comparative Endocrinology·Ursula EllenbergPhilip J Seddon
Jun 7, 2005·Journal of Neurochemistry·Astrid VallèsAntonio Armario
Jul 8, 2008·Journal of Neuroendocrinology·K J Kovács
Apr 17, 2007·The European Journal of Neuroscience·Nina DonnerInga D Neumann
Apr 1, 2011·The Journal of Comparative Neurology·Tamás KoziczAndrey E Ryabinin
Jun 10, 2010·The European Journal of Neuroscience·José Luis ValdésFernando Torrealba
Apr 7, 2005·Neuroscience and Biobehavioral Reviews·Dawn OwenStephen G Matthews

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.