Hypopituitarism after Gamma Knife radiosurgery for pituitary adenomas: a multicenter, international study

Journal of Neurosurgery
Diogo CordeiroJason P Sheehan

Abstract

Recurrent or residual adenomas are frequently treated with Gamma Knife radiosurgery (GKRS). The most common complication after GKRS for pituitary adenomas is hypopituitarism. In the current study, the authors detail the timing and types of hypopituitarism in a multicenter, international cohort of pituitary adenoma patients treated with GKRS. Seventeen institutions pooled clinical data obtained from pituitary adenoma patients who were treated with GKRS from 1988 to 2016. Patients who had undergone prior radiotherapy were excluded. A total of 1023 patients met the study inclusion criteria. The treated lesions included 410 nonfunctioning pituitary adenomas (NFPAs), 262 cases of Cushing’s disease (CD), and 251 cases of acromegaly. The median follow-up was 51 months (range 6–246 months). Statistical analysis was performed using a Cox proportional hazards model to evaluate factors associated with the development of new-onset hypopituitarism. At last follow-up, 248 patients had developed new pituitary hormone deficiency (86 with NFPA, 66 with CD, and 96 with acromegaly). Among these patients, 150 (60.5%) had single and 98 (39.5%) had multiple hormone deficiencies. New hormonal changes included 82 cortisol (21.6%), 135 thyrotropin (35....Continue Reading

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Citations

Aug 20, 2020·Expert Review of Endocrinology & Metabolism·Cristina CapatinaMaria Fleseriu
Jun 22, 2019·Pituitary·Jana JežkováJosef Marek
Sep 12, 2020·Reviews in Endocrine & Metabolic Disorders·Andrea GiustinaShlomo Melmed
Sep 16, 2020·The Journal of Clinical Endocrinology and Metabolism·Xin LianFuquan Zhang
Sep 17, 2021·British Journal of Neurosurgery·Tanja Škorić PolovinaUNKNOWN CRO-ACRO Study Group

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