Hypopituitarism: growth hormone and corticotropin deficiency

Endocrinology and Metabolism Clinics of North America
Cristina Capatina, John A H Wass

Abstract

This article presents an overview of adult growth hormone deficiency (AGHD) and corticotropin deficiency (central adrenal failure, CAI). Both conditions can result from various ailments affecting the hypothalamus or pituitary gland (most frequently a tumor in the area or its treatment). Clinical manifestations are subtle in AGHD but potentially life-threatening in CAI. The diagnosis needs dynamic testing in most cases. Treatment of AGHD is recommended in patients with documented severe deficiency, and treatment of CAI is mandatory in all cases. Despite significant progress in replacement hormonal therapy, more physiologic treatments and more reliable indicators of treatment adequacy are still needed.

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Mar 14, 2017·Current Opinion in Endocrinology, Diabetes, and Obesity·Fabienne LangloisMaria Fleseriu
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Jun 25, 2017·Endocrine·Cesar L Boguszewski

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