Hypoplastic left heart syndrome in the second trimester

Pediatric Pathology & Laboratory Medicine : Journal of the Society for Pediatric Pathology, Affiliated with the International Paediatric Pathology Association
R J Scott, I D Sullivan

Abstract

Hypoplastic left heart syndrome is a relatively common congenital anomaly with a high mortality even after palliative postnatal surgery. The case presented had a normal cardiac cavity and great artery dimensions at 19 weeks of gestation but bright left ventricular myocardial echoes, impaired left ventricular shortening, and no detectable forward flow in the left ventricular outflow tract. Autopsy showed left ventricular subendocardial calcification. This demonstrates a likely early stage in the evolution of hypoplastic left heart syndrome, which has a variable time course. The abnormal left ventricular myocardial performance associated with low left ventricular output results in a failure of growth of the left heart rather than there being a primary failure of embryogenesis.

References

Jul 1, 1992·Archives of Disease in Childhood·S CullenI D Sullivan
Sep 1, 1991·American Journal of Obstetrics and Gynecology·D M BlakeC S Kleinman
Dec 1, 1989·International Journal of Cardiology·L D AllanM J Tynan
Jul 1, 1988·British Heart Journal·H van EgmondA Devloo-Blancquaert

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.