PMID: 7386802Mar 1, 1980Paper

Hyposensitization. Comparing a purified (refined) allergen preparation and a crude aqueous extract from timothy pollen

A B FrostadK Aas


Most extracts used in hyposensitization (immunotherapy) are complex and ill-defined mixtures of a large number of non-antigenic and antigenic components, only a few of the latter being of significance for allergy and allergen specific immunotherapy. A new purified and well-characterized allergen preparation from timothy pollen is now available, and it has been shown to be superior to the corresponding crude aqueous extract in the diagnosis of IgE-mediated human allergy to timothy pollen. This paper describes the results of hyposensitization for 2 years, with the purified preparation and the crude extract compared. The changes in in vivo and in vitro tests following this treatment in 40 patients with allergic rhinitis due to grass pollen are reported. Both patient groups showed a significant decrease in clinical symptom scores when compared with a control group during the grass pollen season. For all groups the symptom scores correlated well with atmospheric pollen counts. Nasal challenge tests showed a significant increase in nasal tolerance to timothy pollen after 2 years of treatment, but nasal tolerance was unchanged in the control group. Nasal function as a criterion for evaluating the effect of specific hyposensitization i...Continue Reading


Jan 1, 1975·International Archives of Allergy and Applied Immunology·K Aas
Apr 1, 1978·Allergy·P S Norman
Jan 1, 1977·International Archives of Allergy and Applied Immunology·O GrimmerK Aas
Jan 1, 1977·International Archives of Allergy and Applied Immunology·A B FrostadK Aas
Jan 1, 1974·The Medical Clinics of North America·P S Norman
Jul 1, 1966·The Journal of Allergy·G A SprecaceH Ziffer


Aug 1, 1982·Allergy·O Osterballe
Nov 1, 1986·Allergy·S L NordvallS G Johansson
Jan 27, 2007·The Cochrane Database of Systematic Reviews·M A CalderonStephen R Durham
Oct 1, 1994·Clinical Otolaryngology and Allied Sciences·E Ellegård, G Karlsson

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