Hyposmia: an underestimated and frequent adverse effect of chemotherapy

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Maria RigaStylianos Kakolyris

Abstract

Optimal function of both the olfactory sensory neurons and the olfactory mucosa is a prerequisite for normal olfactory perception. Both the olfactory neurons and mucosa might be subjects to the neurotoxic and mucotoxic effects of chemotherapy. Despite the recognized importance of olfaction in nutrition and quality of life, the potential olfactory toxicity of chemotherapy regimens has not been adequately assessed. The aim of this study is to investigate whether mucotoxic and/or neurotoxic drugs compromise olfactory performance. Forty-four consecutive patients completed the "Sniffin' Sticks" test, an objective quantitative/qualitative method to assess olfactory function, at diagnosis and immediately before the infusion of the last session of three to four chemotherapy cycles, according to the therapeutic protocol. The patients underwent therapy containing oxaliplatin and antimetabolites (5-FU or capecitabine; O+A group), taxanes and platinum analogues (cisplatin and carboplatin; T+P group), or taxanes and anthracyclines (doxorubicin or liposomal doxorubicin; T+A group). A significant decrease was noted for olfactory threshold (OT), olfactory discrimination (OD), olfactory identification (OI), and the composite threshold-discrimin...Continue Reading

References

Aug 1, 1996·Chemical Senses·P Dalton
May 30, 2001·Nutrition·M J Tisdale
Oct 18, 2001·Acta Oto-laryngologica·M WolfensbergerA Welge-Lüssen
Nov 25, 2003·Chemical Senses·B N LandisJ S Lacroix
Apr 14, 2005·British Journal of Cancer·A YakirevitchM R Pfeffer
Feb 28, 2006·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Carl M PhilpottGeorge E Murty
Jan 5, 2007·The Laryngoscope·Michael KatotomichelakisVassilios Danielides
Aug 5, 2008·The Laryngoscope·M StennerM Damm
Oct 25, 2008·The Laryngoscope·Antti KnaapilaKarri Silventoinen
Mar 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Silke SteinbachNadia Harbeck
Jul 7, 2010·Experimental Brain Research·Lee Sela, Noam Sobel
Apr 7, 2012·Archives of Gynecology and Obstetrics·Silke SteinbachNadia Harbeck
Jun 12, 2012·Clinical Colorectal Cancer·Augusta N UwahWilliam Tester
Aug 28, 2012·Journal of Pain and Symptom Management·Eva-Maria GamperBernhard Holzner
Apr 23, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Noor Al-DasooqiUNKNOWN Mucositis Study Group of Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASC
Nov 26, 2013·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Riddhi M Patel, Jayant M Pinto
May 17, 2014·Cancer Treatment Reviews·N C Miltenburg, W Boogerd

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Citations

Mar 23, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L E SpottenT D Walsh
Aug 5, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Fakih Cihat EravcıHacı Hüseyin Dere
Apr 22, 2017·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Ute Walliczek-DworschakThomas Hummel
May 30, 2021·Chemical Senses·Raul AlfaroMarta Yanina Pepino

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