Hypotensive action of IgG preparations containing aggregates is suppressed by PAF-receptor antagonist BN 52021 and by gadolinium chloride (an agent blocking Kupffer cell function)

Agents and Actions
B JeneiG A Medgyesi

Abstract

The hypotensive side effect of four IgG preparations was studied in a rat model. An unmodified, chromatographically isolated preparation (prepn. C) appeared to induce a transient drop in blood pressure via the kininogen kinin system. A preparation made by ethanol fractionation (prepn. E) and an ethanol-fractionated, modified product (prepn. M) produced an action which does not depend on kininogen activation. No blocking of kininase was required for this effect and it was brought about by prepn. M was devoid of any sizeable prekallikrein activator or kallikrein like proteinase content. The effect was associated by the aggregate fraction of prepn. E, but not with IgG monomers of the same preparation. Animals given these latter types of IgG preparations were refractory to a second dose 24 hours later. The involvement of PAF in the kinin-independent hypotensive action is suggested by the finding that PAF-receptor antagonist BN 52021 prevented the effect and returned the blood pressure close to normality when given during hypotension. A blockade of Kupffer cells brought about by administration of GdCl3 was also found to prevent the effect pointing to the involvement of these type of cells in the reactions.

References

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Citations

Nov 20, 2003·Biologicals : Journal of the International Association of Biological Standardization·Monika KroezGerhard Dickneite
Dec 3, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Zhili XuAndrew P Byrnes
Jun 5, 2013·Expert Review of Clinical Immunology·Adam SunLeman Yel
Sep 4, 2007·The Journal of Allergy and Clinical Immunology·Fred D Finkelman
Sep 20, 2005·Biologicals : Journal of the International Association of Biological Standardization·Arpád SzencziPéter Závodszky

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